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Table 3 Comparison between CKD patients regarding FGF23 RS7955866 polymorphism genotypes

From: Fibroblast growth factor-23 rs7955866 polymorphism and risk of chronic kidney disease

Parameter

GG (N = 34)

GA (N = 28)

AA (N = 10)

Statistical test

P

Hypertension Grade

2 (0.75–3)

2.5 (1–3)

4 (2.75–4.25)

KWH

0.003**

S. Creatinine (mg/dL)

1.45 (1.2–1.7)

1.65 (1.1–2)

1.50 (1.1–1.83)

KWH

0.619

GFR-EPI (mL/min/1.73)

45.68 (36.75–60.52)

42.53 (34.01–64.44)

41.84 (37.55–64.76)

KWH

0.913

Proteinuria (gm/day)

2.16 (1.17–3.96)

2.18 (1.09–4.14)

1.83 (1.19–3.96)

KWH

0.988

S. Urea (mg/dL)

79.91 ± 20.56

84.07 ± 21.83

79.30 ± 18.34

ANOVA

0.693

S. Uric Acid (mg/dL)

7.74 ± 2.43

7.33 ± 2.33

6.35 ± 2.61

ANOVA

0.278

S. Proteins (gm/dL)

6.41 ± 0.78

6.39 ± 0.79

5.95 ± 0.77

ANOVA

0.242

S. Albumin (gm/dL)

3.35 (2.58–3.73)

3.15 (2.9–3.4)

2.5 (2.45–3.05)

KWH

0.007**

S. Calcium (mg/dL)

9.04 ± 0.86

9.24 ± 0.86

8.81 ± 0.95

ANOVA

0.37

S. Phosphorus (mg/dL)

4.75 (4.10–5.93)

4.55 (3.95–5.1)

5.3 (4.13–5.78)

KWH

0.368

S. iPTH (pg/mL)

127.5 (101.3–192.3)

178 (111–221)

133.5 (74.5–237)

KWH

0.387

S. Vitamin D3 (ng/mL)

14.75 (12–19.75)

13.25 (11.13–22)

17 (14.25–26.1)

KWH

0.268

S. iFGF23 (pg/mL)

676.71 (409.49–916.85)

729.19 (544.03–970.98)

879.53 (791.83–1486.7)

KWH

0.038*

Hemoglobin (gm/dL)

10.49 ± 1.28

10.22 ± 1.20

10.42 ± 1.33

ANOVA

0.708

WBCs (k/uL)

7.75 (5.78–9.85)

7.65 (6.75–9.45)

5.78 (5.13–7.33)

KWH

0.09

Platelets (k/uL)

304.24 ± 77.12

282.18 ± 68.27

311.20 ± 84.47

ANOVA

0.416

  1. CKD, chronic kidney disease; Hypertension grades are numbered 0 (none) through 5 (most severe); S., serum; GFR-EPI, glomerular filtration rate by CKD epidemiology collaboration equation; iPTH, intact parathyroid hormone; iFGF23, intact fibroblast growth factor 23; WBCs, white blood cells; k, one thousand; ANOVA, analysis of variance; KWH, Kruskal–Wallis H Test
  2. Data are expressed as either mean ± SD or median (interquartile range), *: significant (P < 0.05), **: highly significant (P < 0.01)