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Table 4 Statistical correlations of "A" allele load of FGF23 RS7955866 polymorphism in CKD patients

From: Fibroblast growth factor-23 rs7955866 polymorphism and risk of chronic kidney disease

Parameter

Assumed mode of "A' allele inheritance

Codominant

Dominant

Recessive

r

P

r

P

r

P

Hypertension grade

0.385

0.001**

0.324

0.006**

0.349

0.003**

S. Creatinine

0.061

0.612

0.089

0.455

 − 0.035

0.771

GFR-EPI

 − 0.025

0.832

 − 0.038

0.750

0.016

0.891

Proteinuria

0.018

0.881

0.019

0.876

0.008

0.949

S. Urea

0.023

0.846

0.044

0.712

 − 0.037

0.759

S. Uric Acid

 − 0.170

0.155

 − 0.137

0.25

 − 0.166

0.163

S. Proteins

 − 0.124

0.3

 − 0.075

0.531

 − 0.181

0.128

S. Albumin

 − 0.29

0.014*

 − 0.199

0.094

 − 0.368

0.001**

S. Calcium

0.017

0.887

0.069

0.564

 − 0.113

0.344

S. Phosphorus

 − 0.100

0.402

 − 0.138

0.247

0.036

0.765

S. iPTH

0.015

0.901

0.066

0.58

 − 0.113

0.344

S. Vitamin D3

0.094

0.431

0.036

0.767

0.189

0.113

Hemoglobin

 − 0.071

0.551

 − 0.092

0.44

0.012

0.923

WBCs

 − 0.11

357

 − 029

81

 − 0.25

0.034*

Platelets

 − 0.061

0.609

 − 0.1

0.404

0.058

0.629

S. iFGF23

0.259

0.028*

0.194

0.102

0.29

0.014*

S. iFGF23, controlled for GFR

0.289

0.015*

  

0.341

 0.004**

S. iFGF23, controlled for S. Phosphorus

0.311

0.008**

  

0.344

 0.003**

S. iFGF23, controlled for S. iPTH

0.262

0.027*

  

0.32

 0.006**

  1. CKD, chronic kidney disease; S., serum; GFR-EPI, glomerular filtration rate by CKD epidemiology collaboration equation; iPTH, intact parathyroid hormone; iFGF23, intact fibroblast growth factor 23; WBCs, white blood cells; r, Spearman correlation coefficient
  2. *: significant (P < 0.05), **: highly significant (P < 0.01)