Table 5 Associations between MTHFR C677T SNP, TYMS tandem repeat, DNMT3B − 149C>T and TYMS 3′-UTR 1494del6 with breast cancer risk in Egyptian women

The MTHFR (C677T) genotypes and alleles frequency in the studied groups

Genotype

(n = 100)

(n = 100)

 CC

^MCp = 

0.288

Ref

 CT

1.493

0.78–2.84

 TT

3.397

0.35–33.43

 CT + TT

0.154

1.575

0.84–2.95

Allele frequency

(n = 200)

(n = 200)

 C

0.121

Ref

 T

1.556

0.89–2.73

The TYMS tandem repeat genotypes and alleles frequency in the studied groups

Genotype

(n = 100)

(n = 100)

 2R/2R

–

–

 2R/3R

2.232

1.21–4.12

 3R/3R

–

–

Allele frequency

(n = 200)

(n = 200)

 2R

–

–

 3R

1.461

0.96–2.21

The DNMT3B − 149C>T genotypes and alleles frequency in the studied groups

Genotype

(n = 100)

(n = 100)

 CC®

^MCp

< 0.001*

Ref

 CT

6.907

3.58–13.32

 TT

–

–

 CT + TT

59

59.0

17

17.0

< 0.001*

7.026

3.64–13.55

Allele frequency

(n = 200)

(n = 200)

 C

< 0.001*

Ref

 T

4.613

2.58–8.25

The TYMS 3′-UTR 1494del6 genotypes and alleles frequency in the studied groups

Genotype

(n = 100)

(n = 100)

 (+ 6/ + 6)®

Ref

 (+ 6/− 6)

0.844

 (− 6/− 6)

3.294

 (− 6/− 6) + (+ 6/− 6)

1.899

Allele frequency

(n = 200)

(n = 200)

 + 6

Ref

 − 6

2.483