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Table 6 Expression level of TYMS, MTHFR and DNMT3B genes in breast cancer tissues compared to normal adjacent tissue

From: Genetic polymorphisms and gene expression of one-carbon metabolizing enzymes and their relation to breast cancer

Expression fold

Tumor

(n = 10)

Normal adjacent tissue

(n = 10)

U

P

Expression level of TYMS gene

Min–Max

0.57–1.62

1.0–1.0

30.0

0.143

Mean ± SD

0.93 ± 0.39

1.0 ± 0.0

Median

0.73

1.0

Expression fold

Breast cancer patients

(n = 10)

Control**

(n = 10)

U

P

Expression level of MTHFR gene

Min–Max

0.27–0.93

1.0–1.0

0.0*

< 0.001*

Mean ± SD

0.57 ± 0.20

1.0 ± 0.0

Median

0.62

1.0

Expression fold

Tumor tissue

(n = 10)

Normal adjacent tissue

(n = 10)

U

P

Expression level of DNMT3B gene

Min–Max

1.02–2.95

1.0–1.0

0.0*

< 0.001*

Mean ± SD

1.81 ± 0.63

1.0 ± 0.0

Median

1.65

1.0

  1. U: Mann–Whitney test
  2. P: P value for comparing between the studied groups
  3. *Statistically significant at P ≤ 0.05
  4. **Control: normal adjacent tissues from patients