Skip to main content

Table 1 Logistic regression and Hardy–Weinberg analyses of TLR10 gene SNPs in multiple sclerosis patients and healthy controls

From: Toll-like receptor 10 gene polymorphism and risk of multiple sclerosis among Iraqi patients

SNP

Allele/genotype

MSa

HCa

OR

95% CI

p-value (pc)

N

%

N

%

rs200395112 T/A

T

52

31.3

20

32.3

Reference

 

0.874 (1.0)

A

114

68.7

42

67.7

1.04

0.56–1.94

 

TT

11

13.3

1

3.2

Reference

  

TA

30

36.1

18

58.1

0.15

0.02–1.21

0.082 (0.246)

AA

42

50.6

12

38.7

0.32

0.04–2.51

0.434 (1.0)

HWE-p-value

   

0.067

    

rs201802754 A/T

A

48

28.9

20

32.3

Reference

  

T

118

71.1

42

67.7

1.17

0.63–2.19

0.629 (1.0)

AA

9

10.8

1

3.2

Reference

  

AT

30

36.1

18

58.1

0.19

0.02–1.50

0.142 (0.426)

TT

44

53.0

12

38.7

0.41

0.05–3.28

0.672 (1.0)

HWE-p-value

   

0.067

    

rs201228097 T/A

T

50

30.1

20

32.3

Reference

  

A

116

69.9

42

67.7

1.10

0.59–2.06

0.75 (1.0)

TT

9

10.8

1

3.2

Reference

  

TA

32

38.6

18

58.1

0.20

0.02–1.60

0.148 (0.444)

AA

42

50.6

12

38.7

0.39

0.05–3.13

0.672 (1.0)

HWE-p-value

   

0.067

    

rs113588825 G/A

G

147

88.5

75

87.2

Reference

  

A

19

11.5

11

12.8

0.88

0.40–1.94

0.838 (1.0)

GG

67

80.7

32

74.4

Reference

  

GA

13

15.7

11

25.6

0.56

0.23–1.39

0.238 (0.714)

AA

3

3.6

0

0.0

3.37

0.18–64.40

0.55 (1.0)

HWE-p-value

   

0.336

    

rs10004195 T/A

T

81

48.2

49

53.3

Reference

  

A

87

51.8

43

46.7

1.22

0.74–2.03

0.517 (1.0)

TT

24

28.6

12

26.1

Reference

  

TA

33

39.3

25

54.3

0.66

0.28–1.55

0.391 (1.0)

AA

27

32.1

9

19.6

1.50

0.55–4.09

0.605 (1.0)

HWE-p-value

   

0.534

    

rs10034903 C/G

C

84

50.6

62

53.5

Reference

  

G

82

49.4

54

46.5

1.12

0.70–1.80

0.717 (1.0)

CC

27

32.5

14

24.1

Reference

  

CG

30

36.1

34

58.6

0.46

0.20–1.02

0.072 (0.216)

GG

26

31.3

10

17.2

1.35

0.52–3.51

0.626 (1.0)

HWE-p-value

   

0.175

    

rs10012016 G/A/C

G

143

84.1

132

79.5

Reference

  

A

27

15.9

34

20.5

0.73

0.42–1.28

0.322 (1.0)

GG

62

72.9

55

66.3

Reference

  

GA

19

22.4

22

26.5

0.77

0.38–1.56

0.475 (1.0)

AA

4

4.7

6

7.2

0.59

0.16–2.18

0.519 (1.0)

HWE-p-value

   

0.09

    

rs10012017 G/T

G

89

53.0

91

55.5

Reference

  

T

79

47.0

73

44.5

1.11

0.72–1.70

0.661 (1.0)

GG

28

33.3

26

31.7

Reference

  

GT

33

39.3

39

47.6

0.79

0.39–1.58

0.590 (1.0)

TT

23

27.4

17

20.7

1.26

0.56–2.84

0.677 (1.0)

HWE-p-value

   

0.736

    

rs33994884 T/Del

T

133

78.2

96

64.0

Reference

  

Del

37

21.8

54

36.0

0.49

0.30–0.81

0.006 (0.018)

TT

59

69.4

34

45.3

Reference

  

T/Del

15

17.6

28

37.3

0.31

0.15–0.65

0.003 (0.009)

Del/Del

11

12.9

13

17.3

0.49

0.20–1.20

0.161 (0.483)

HWE-p-value

   

0.101

    

rs28393318 A/G

A

102

60.0

80

53.3

Reference

  

G

68

40.0

70

46.7

0.76

0.49–1.19

0.258 (1.0)

AA

42

49.4

23

30.7

Reference

  

AG

18

21.2

34

45.3

0.29

0.14–0.62

0.002 (0.006)

GG

25

29.4

18

24.0

0.76

0.35–1.66

0.547 (1.0)

HWE-p-value

   

0.439

    
  1. p: Two-tailed Fisher's exact probability; pc: Bonferroni correction probability(significant p-value is indicated in bold)
  2. SNP single nucleotide polymorphism, Del deletion, HWE Hardy–Weinberg equilibrium, MS multiple sclerosis, HC healthy controls, OR odds ratio adjusted for age and gender, CI confidence interval
  3. aThe number of patients and controls for each SNP varies due to low-quality reads of some DNA sequences