From: Toll-like receptor 10 gene polymorphism and risk of multiple sclerosis among Iraqi patients
SNP | Allele/genotype | MSa | HCa | OR | 95% CI | p-value (pc) | ||
---|---|---|---|---|---|---|---|---|
N | % | N | % | |||||
rs200395112 T/A | T | 52 | 31.3 | 20 | 32.3 | Reference | 0.874 (1.0) | |
A | 114 | 68.7 | 42 | 67.7 | 1.04 | 0.56–1.94 | ||
TT | 11 | 13.3 | 1 | 3.2 | Reference | |||
TA | 30 | 36.1 | 18 | 58.1 | 0.15 | 0.02–1.21 | 0.082 (0.246) | |
AA | 42 | 50.6 | 12 | 38.7 | 0.32 | 0.04–2.51 | 0.434 (1.0) | |
HWE-p-value | 0.067 | |||||||
rs201802754 A/T | A | 48 | 28.9 | 20 | 32.3 | Reference | ||
T | 118 | 71.1 | 42 | 67.7 | 1.17 | 0.63–2.19 | 0.629 (1.0) | |
AA | 9 | 10.8 | 1 | 3.2 | Reference | |||
AT | 30 | 36.1 | 18 | 58.1 | 0.19 | 0.02–1.50 | 0.142 (0.426) | |
TT | 44 | 53.0 | 12 | 38.7 | 0.41 | 0.05–3.28 | 0.672 (1.0) | |
HWE-p-value | 0.067 | |||||||
rs201228097 T/A | T | 50 | 30.1 | 20 | 32.3 | Reference | ||
A | 116 | 69.9 | 42 | 67.7 | 1.10 | 0.59–2.06 | 0.75 (1.0) | |
TT | 9 | 10.8 | 1 | 3.2 | Reference | |||
TA | 32 | 38.6 | 18 | 58.1 | 0.20 | 0.02–1.60 | 0.148 (0.444) | |
AA | 42 | 50.6 | 12 | 38.7 | 0.39 | 0.05–3.13 | 0.672 (1.0) | |
HWE-p-value | 0.067 | |||||||
rs113588825 G/A | G | 147 | 88.5 | 75 | 87.2 | Reference | ||
A | 19 | 11.5 | 11 | 12.8 | 0.88 | 0.40–1.94 | 0.838 (1.0) | |
GG | 67 | 80.7 | 32 | 74.4 | Reference | |||
GA | 13 | 15.7 | 11 | 25.6 | 0.56 | 0.23–1.39 | 0.238 (0.714) | |
AA | 3 | 3.6 | 0 | 0.0 | 3.37 | 0.18–64.40 | 0.55 (1.0) | |
HWE-p-value | 0.336 | |||||||
rs10004195 T/A | T | 81 | 48.2 | 49 | 53.3 | Reference | ||
A | 87 | 51.8 | 43 | 46.7 | 1.22 | 0.74–2.03 | 0.517 (1.0) | |
TT | 24 | 28.6 | 12 | 26.1 | Reference | |||
TA | 33 | 39.3 | 25 | 54.3 | 0.66 | 0.28–1.55 | 0.391 (1.0) | |
AA | 27 | 32.1 | 9 | 19.6 | 1.50 | 0.55–4.09 | 0.605 (1.0) | |
HWE-p-value | 0.534 | |||||||
rs10034903 C/G | C | 84 | 50.6 | 62 | 53.5 | Reference | ||
G | 82 | 49.4 | 54 | 46.5 | 1.12 | 0.70–1.80 | 0.717 (1.0) | |
CC | 27 | 32.5 | 14 | 24.1 | Reference | |||
CG | 30 | 36.1 | 34 | 58.6 | 0.46 | 0.20–1.02 | 0.072 (0.216) | |
GG | 26 | 31.3 | 10 | 17.2 | 1.35 | 0.52–3.51 | 0.626 (1.0) | |
HWE-p-value | 0.175 | |||||||
rs10012016 G/A/C | G | 143 | 84.1 | 132 | 79.5 | Reference | ||
A | 27 | 15.9 | 34 | 20.5 | 0.73 | 0.42–1.28 | 0.322 (1.0) | |
GG | 62 | 72.9 | 55 | 66.3 | Reference | |||
GA | 19 | 22.4 | 22 | 26.5 | 0.77 | 0.38–1.56 | 0.475 (1.0) | |
AA | 4 | 4.7 | 6 | 7.2 | 0.59 | 0.16–2.18 | 0.519 (1.0) | |
HWE-p-value | 0.09 | |||||||
rs10012017 G/T | G | 89 | 53.0 | 91 | 55.5 | Reference | ||
T | 79 | 47.0 | 73 | 44.5 | 1.11 | 0.72–1.70 | 0.661 (1.0) | |
GG | 28 | 33.3 | 26 | 31.7 | Reference | |||
GT | 33 | 39.3 | 39 | 47.6 | 0.79 | 0.39–1.58 | 0.590 (1.0) | |
TT | 23 | 27.4 | 17 | 20.7 | 1.26 | 0.56–2.84 | 0.677 (1.0) | |
HWE-p-value | 0.736 | |||||||
rs33994884 T/Del | T | 133 | 78.2 | 96 | 64.0 | Reference | ||
Del | 37 | 21.8 | 54 | 36.0 | 0.49 | 0.30–0.81 | 0.006 (0.018) | |
TT | 59 | 69.4 | 34 | 45.3 | Reference | |||
T/Del | 15 | 17.6 | 28 | 37.3 | 0.31 | 0.15–0.65 | 0.003 (0.009) | |
Del/Del | 11 | 12.9 | 13 | 17.3 | 0.49 | 0.20–1.20 | 0.161 (0.483) | |
HWE-p-value | 0.101 | |||||||
rs28393318 A/G | A | 102 | 60.0 | 80 | 53.3 | Reference | ||
G | 68 | 40.0 | 70 | 46.7 | 0.76 | 0.49–1.19 | 0.258 (1.0) | |
AA | 42 | 49.4 | 23 | 30.7 | Reference | |||
AG | 18 | 21.2 | 34 | 45.3 | 0.29 | 0.14–0.62 | 0.002 (0.006) | |
GG | 25 | 29.4 | 18 | 24.0 | 0.76 | 0.35–1.66 | 0.547 (1.0) | |
HWE-p-value | 0.439 |