Toll-like receptor 10 gene polymorphism and risk of multiple sclerosis among Iraqi patients

Egyptian Journal of Medical Human Genetics

Table 2 Allele and genotype frequencies of TLR10 gene SNPs stratified by Expanded Disability Status Scale groups in multiple sclerosis patients

SNP	Allele/genotype	EDSS				p-value
		< 3.0		≥ 3.0
		N	%	N	%
rs200395112 T/A	T	29	30.8	23	31.9	1.0
	A	65	69.2	49	68.0
	TT	5	10.6	6	16.7	0.558
	TA	19	40.4	11	30.6
	AA	23	48.9	19	52.8
rs201802754 A/T	A	25	26.6	23	31.9	0.492
	T	69	73.4	49	68.1
	AA	4	8.5	5	13.9	0.722
	AT	17	36.2	13	36.1
	TT	26	55.3	18	50.0
rs201228097 T/A	T	27	28.7	23	31.9	0.733
	A	67	71.3	49	68.1
	TT	4	8.5	5	13.9	0.724
	TA	19	40.4	13	36.1
	AA	24	51.1	18	50.0
rs113588825 G/A	G	81	86.2	66	91.7	0.33
	A	13	13.8	6	8.3
	GG	36	76.6	31	86.1	0.551
	GA	9	19.1	4	11.1
	AA	2	4.3	1	2.8
rs10004195 T/A	T	47	49.0	34	47.2	0.877
	A	49	51.0	38	52.8
	TT	13	27.1	11	30.6	0.618
	TA	21	43.8	12	33.3
	AA	14	29.2	13	36.1
rs10034903 C/G	C	48	51.1	36	50.0	1.0
	G	46	48.9	36	50.0
	CC	15	31.9	12	33.3	0.890
	CG	18	38.3	12	33.3
	GG	14	29.8	12	33.3
rs10012016 G/A/C	G	81	82.7	62	86.1	0.672
	A	17	17.3	10	13.9
	GG	35	71.4	27	75.0	0.767
	GA	11	22.4	8	22.2
	AA	3	6.1	1	2.8
rs10012017 G/T	G	46	47.9	43	59.7	0.160
	T	50	52.1	29	40.3
	GG	12	25.0	16	44.4	0.158
	GT	22	45.8	11	30.6
	TT	14	29.2	9	25.0
rs33994884 T/Del	T	72	73.5	61	84.7	0.092
	Del	26	26.5	11	15.2
	TT	32	65.3	27	75.0	0.22
	T/Del	8	16.3	7	19.4
	Del/Del	9	18.4	2	5.6
rs28393318 A/G	A	61	62.3	41	56.9	0.142
	G	37	37.7	31	43.1
	AA	25	51.0	17	47.2	0.788
	AG	11	22.4	7	19.4
	GG	13	26.5	12	33.3

For simplicity, the patients were divided into two groups: < 3.0 [no to moderate disability] and ≥ 3.0 [higher disability]); p: Pearson Chi-square test probability
SNP single nucleotide polymorphism, Del deletion, EDSS Expanded Disability Status Scale (The EDSS scale ranges from 0 [normal neurological exam] to 10 [death due to MS] in 0.5 unit increments that represent higher levels of disability