Toll-like receptor 10 gene polymorphism and risk of multiple sclerosis among Iraqi patients

Egyptian Journal of Medical Human Genetics

Table 3 Estimated frequencies of nine-locus haplotypes of TLR10 gene SNPs (in the order: rs200395112, rs201802754, rs201228097, rs113588825, rs10004195, rs10034903, rs10012016, rs10012017 and rs28393318) among multiple sclerosis patients and healthy controls

Haplotype	Frequency			OR	95% CI	p-value (pc)
Haplotype	All	MS	HC	OR	95% CI	p-value (pc)
A-T-A-G-A-G-G-G-A	0.230	0.241	0.210	1.20	0.64–2.24	0.637 (1.0)
T-A-T-G-T-C-G-T-G	0.154	0.132	0.198	0.62	0.31–1.24	0.175 (1.0)
A-A-A-G-A-G-G-G-A	0.109	0.091	0.144	0.61	0.27–1.37	0.231 (1.0)
A-T-A-G-A-G-G-T-A	0.069	0.102	0.003	9.70	1.28–73.31	0.003 (0.03)
T-A-T-G-T-C-G-G-G	0.061	0.088	0.009	8.44	1.11–64.30	0.012 (0.12)
T-A-T-G-T-C-G-T-A	0.060	0.051	0.079	0.58	0.20–1.64	0.381 (1.0)
A-T-A-A-T-C-A-T-G	0.049	0.039	0.069	0.48	0.16–1.46	0.294 (1.0)
A-T-A-G-A-G-G-G-G	0.030	0.018	0.052	0.38	0.08–1.71	0.136 (1.0)
A-A-A-A-T-C-A-T-A	0.023	0.012	0.045	0.25	0.05–1.38	0.098 (0.98)
A-T-A-G-T-C-A-T-G	0.022	0.003	0.058	0.10	0.01–0.85	0.005 (0.05)

p: Pearson Chi-square test probability; pc: Bonferroni correction p-value. Significant p-value is indicated in bold
MS multiple sclerosis, HC healthy controls, OR odds ratio, CI confidence interval