The genetic influence of PD-1/PD-L1 axis single nucleotide polymorphisms on the incidence of type 1 diabetes mellitus in pediatric Egyptian patients

Egyptian Journal of Medical Human Genetics

Table 5 Relation between demographic data and PDL-1 rs4143815 and rs2297137 in the patient group

SNP		Genotypes	Age at diagnosis (years)	p value	BMI (Mean ± SD)	p value	Gender		p value
SNP		Genotypes	Age at diagnosis (years)	p value	BMI (Mean ± SD)	p value	Male	Female	p value
PDL-1 rs4143815 C/G	General	CC	4.15 ± 0.07	NA	44.6 ± 0.0	NA	0 (0%)	2 (3.8)	NA
		CG	2.71 ± 0.53		17.9 ± 2.4		14 (50%)	16 (30.8%)
		GG	2.48 ± 0.61		18.5 ± 3.2		14 (50%)	34 (65.4%)
	Dominant	CC	4.15 ± 0.07	NA	44.6 ± 0.0	NA	0 (0%)	2 (3.8)	NA
	Dominant	CG + GG	2.97 ± 0.58	NA	18.3 ± 2.9	NA	28 (100%)	50 (96.2%)	NA
	Recessive	GG	2.84 ± 0.61	0.771	18.5 ± 3.2	0.372	14 (50%)	34 (65.4%)	0.180
	Recessive	CG + CC	2.80 ± 0.63	0.771	19.5 ± 7.0	0.372	14 (50%)	18 (34.6%)	0.180
PDL-1 rs2297137 A/G	General	AA	2.20 ± 0.14	NA	25.0 ± 0.0	NA	0 (0%)	2 (3.8%)	NA
		GA	2.89 ± 0.61		20.3 ± 7.7		12 (42.9%)	12 (23.1%)
		GG	2.82 ± 0.62		18.1 ± 3.0		16 (57.1%)	38 (73.1%)
	Dominant	AA	2.20 ± 0.14	NA	25.0 ± 0.0	NA	0 (0%)	2 (3.8%)	NA
	Dominant	GA + GG	2.84 ± 0.61	NA	18.8 ± 5.0	NA	28(100%)	50 (96.2%)	NA
	Recessive	GG	2.82 ± 0.62	0.897	18.1 ± 3.0	0.109	16 (57.1%)	38 (73.1%)	0.147
	Recessive	GA + AA	2.83 ± 0.61	0.897	20.6 ± 7.5	0.109	12 (42.9%)	14 (26.9%)	0.147

BMI, body mass index; NA, non-applicable; SNP, single nucleotide polymorphism; SD, standard deviation; PDL-1, programmed death-ligand 1
^*p value is non-applicable due to the small number of cases