Table 4 Relationship between VEGF-A rs3025020 and rs3025039 genotypes and different studied parameters inT2DM with mixed diabetic complications
Mixed complications | rs3025020 genotypes | rs3025039 genotypes | ||||||
|---|---|---|---|---|---|---|---|---|
CC N = 12 | CT N = 11 | TT N = 3 | P value | CC N = 10 | CT N = 12 | TT N = 4 | P value | |
Parameters | Mean ± SD | Mean ± SD | Mean ± SD | K | Mean ± SD | Mean ± SD | Mean ± SD | K |
Age (years) | 67.6 ± 8.9 | 60.9 ± 5.5 | 66.7 ± 6.1 | 0.01 | 59.9 ± 8.1 | 69.2 ± 4.2 | 63.0 ± 9.1 | 0.01 |
Age of onset (years) | 57.8 ± 8.3 | 51.5 ± 5.1 | 56.0 ± 7.2 | 0.09 | 51.2 ± 7.0 | 57.3 ± 5.1 | 56.8 ± 11.6 | 0.12 |
Disease’s duration (Years) | 10.2 ± 4.8 | 6.5 ± 4.7 | 10.7 ± 1.2 | 0.80 | 9.1 ± 5.0 | 11.8 ± 3.3 | 6.3 ± 2.9 | 0.04 |
FBG (mg/dl) | 290.7 ± 76.4 | 317.3 ± 78.5 | 256.7 ± 34.1 | 0.39 | 297.1 ± 88.6 | 284.3 ± 65.0 | 341.3 ± 60.9 | 0.45 |
HbA1c % | 9.1 ± 1.4 | 9.0 ± 1.3 | 8.1 ± 0.2 | 0.39 | 9.4 ± 1.5 | 8.6 ± 0.9 | 8.9 ± 1.7 | 0.54 |
Cholesterol (mg/dl) | 208.2 ± 29.5 | 204.5 ± 27.6 | 200.0 ± 0.0 | 0.77 | 201.5 ± 28.9 | 201.7 ± 20.7 | 228.0 ± 30.6 | 0.27 |
TG (mg/dl) | 130.3 ± 22.0 | 135.9 ± 14.3 | 143.7 ± 7.8 | 0.49 | 135.2 ± 17.2 | 134.3 ± 21.5 | 131.5 ± 8.3 | 0.64 |
HDL-C (mg/dl) | 37.5 ± 1.7 | 37.3 ± 2.4 | 38.7 ± 3.5 | 0.70 | 37.3 ± 1.1 | 38.1 ± 2.8 | 36.5 ± 1.9 | 0.53 |
LDL-C (mg/dl) | 133.0 ± 26.6 | 139.2 ± 28.3 | 132.3 ± 2.3 | 0.82 | 131.0 ± 25.2 | 134.3 ± 18.7 | 150.5 ± 42.3 | 0.58 |
ACR (mg/gm creatinine) | 764.4 ± 214.0 | 729.1 ± 336.9 | 597.0 ± 407.4 | 0.83 | 729.1 ± 210.5 | 741.4 ± 321.2 | 699.0 ± 408.0 | 0.82 |
Creatinine (mg/dl) | 5.7 ± 1.7 | 5.8 ± 3.0 | 5.0 ± 3.9 | 0.92 | 6.0 ± 1.9 | 5.5 ± 2.7 | 5.3 ± 3.6 | 0.95 |
BUN (mg/dl) | 59.9 ± 9.5 | 54.7 ± 20.4 | 45.3 ± 30.1 | 0.69 | 59.2 ± 8.8 | 54.8 ± 21.0 | 52.0 ± 24.1 | 0.98 |
Uric acid (mg/dl) | 7.7 ± 1.3 | 7.2 ± 2.0 | 6.6 ± 2.6 | 0.83 | 7.4 ± 1.4 | 7.4 ± 2.0 | 7.0 ± 2.2 | 0.92 |
eGFR (ml/min/1.73 m2) | 12.7 ± 3.5 | 25.5 ± 32.5 | 33.3 ± 37.8 | 0.83 | 12.5 ± 4.8 | 22.7 ± 26.3 | 33.6 ± 44.1 | 0.92 |
VEGF-A(pg/ml) | 167.9 ± 157.1 | 292.4 ± 393.2 | 241.7 ± 142.2 | 0.40 | 136.0 ± 45.5 | 245.4 ± 219.9 | 412.8 ± 625.2 | 0.83 |