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Table 2 Deleterious missense SNPs in the human SLC47A2 gene determined by bioinformatic tools

From: Analysis of missense SNPs in the SLC47A1 and SLC47A2 genes affecting the pharmacokinetics of metformin: Computational approach

SNP ID

Nucleotide substitution

Amino acid change

SIFT result

SIFT score

PolyPhen-2 result

PolyPhen-2 score

PROVEAN result (cut-off = − 2.5)

PROVEAN score

PhD-SNP result

PhD-SNP RI

PMut result

PMut score

rs111838634

T/C

K106E

DEL

0.005

Pro-damg

0.999

DEL

− 3.667

Diseased

5

Neutral

0.26

rs112362579

A/T

I158N

DEL

0.001

Pro-damg

0.973

DEL

− 6.254

Diseased

6

Diseased

0.83

rs139778919

A/G

L112P

DEL

0.001

Pro-damg

1.000

DEL

− 6.831

Diseased

6

Diseased

0.83

rs141717616

G/A

P125S

DEL

0

Pro-damg

1.000

DEL

− 7.960

N

4

Diseased

0.64

rs146901447

G/A

P162L

DEL

0.002

Pro-damg

1.000

DEL

− 9.850

Diseased

8

Neutral

0.28

rs147661457

G/T

H61Q

DEL

0

Pro-damg

1.000

DEL

− 7.782

Diseased

3

Neutral

0.49

rs148039766

G/T

A128E

DEL

0.001

Pro-damg

1.000

DEL

− 4.975

N

3

Diseased

0.80

rs148775490

C/T

G81R

DEL

0.002

Pro-damg

1.000

DEL

− 7.167

Diseased

5

Diseased

0.83

rs199674976

G/T

A298D

DEL

0.004

Pro-damg

0.991

DEL

− 4.380

Diseased

7

Neutral

0.28

rs373244724

T/C

Y273C

DEL

0

Pro-damg

1.000

DEL

− 8.066

Diseased

4

Neutral

0.40

rs374762995

A/C

V118G

DEL

0.001

Pro-damg

0.973

DEL

− 6.865

Diseased

4

Diseased

0.80

  1. DEL deleterious, pro-damg probably damaging