Skip to main content

Table 3 Effects of missense SNPs on MATE1 protein stability by MUpro and I-Mutant 3.0

From: Analysis of missense SNPs in the SLC47A1 and SLC47A2 genes affecting the pharmacokinetics of metformin: Computational approach

SNP ID

Amino acid change

MUpro resulta

MUpro DDG

I-Mutant result*

I-Mutant DDG

I-Mutant RI

rs77138970

R118Q

Decrease

− 0.5256

Decrease

− 0.52

7

rs77630697

G64D

Decrease

− 0.9342

Decrease

− 1.03

6

rs143542564

S151F

Increase

0.4154

Increase

0.35

4

rs145557304

Y203C

Decrease

− 1.4685

Decrease

− 0.72

2

rs145720500

M269T

Decrease

− 1.5494

Decrease

− 0.69

7

rs147768037

G424R

Decrease

− 0.6050

Decrease

− 0.44

4

rs149729794

P186T

Decrease

− 1.2193

Decrease

− 1.30

9

rs200191180

L116P

Decrease

− 1.5929

Decrease

− 1.22

3

rs200450505

G113D

Decrease

− 0.2109

Decrease

− 0.95

5

rs201666623

G285V

Decrease

− 0.4049

Decrease

− 0.24

2

rs202140517

G67S

Decrease

− 0.9497

Decrease

− 1.18

7

rs372035240

W274L

Decrease

− 0.2482

Decrease

− 0.47

6

rs375863644

R261C

Decrease

− 1.0377

Decrease

− 0.67

3

  1. aProtein stability: Increase or decrease; DDG values are calculated in kcal/mol