Table 1 Summary of main studies about CFTR and cancer
From: Cystic fibrosis transmembrane conductance regulator (CFTR): beyond cystic fibrosis
Authors | Setting | Sample size | Major findings |
|---|---|---|---|
Shi et al. [19] | Population-based study | 498.930 individuals aged 40–69 years | F508del carriers: ↑risk for colorectal, gallbladder and biliary tract, thyroid cancer, non-Hodgkin's lymphoma ↓ risk for lung cancer no risk for pancreatic cancer |
Colak et al. [11] | Population-based study median follow-up of 9 years | 108.034 individuals | F508del carriers: ↑ risk for lung cancer ↑ chronic bronchitis ↑ bronchiectasis, |
Schubert et al. [12] | Case control study | 121 pancreatic cancer 102 idiopathic chronic pancreatitis 130 controls | CFTR mutation carriers (34 different mutations): no risk for pancreatic cancer |
Cazacu et al. [13] | Meta-analysis 5 studies | 1674 pancreatic cancer 19.036 controls | F508del, W1282X, ΔI507 and S549R carriers: ↑ risk for pancreatic cancer |
Case series | 40 individuals with esophageal cancer | CFTR downregulation ↑ NF-κB-p65 ↑ NF-κB-p50 | |
Liu C et al. [16] | Case series Case control study | 35 colorectal and adjacent tissue samples | CFTR downregulation CFTR overexpression suppress tumor proliferation |
Liu K et al. [18] | Colorectal cancer cells | CFTR knockdown cells induces mitochondrial dysfunction through: ↓ HSP90 ↓ AKT, ERK ↓ Bcl-2 | |
Liu K et al. [20] | 19 breast cancer and normal tissue samples | CFTR promoter hypermethylation associated with invasion and worse prognosis | |
Xu et al. [26] | 83 epithelial ovarian cancer samples | CFTR is overexpressed in ovarian cancer | |
Peng et al. [27] | 357 cervical tissue samples Cervical cell lines | CFTR is overexpressed in cervical cancer and correlates with prognosis, stage and metastasis | |
Wu et al. [28] | Case control study | 135 cervical tissue samples | CFTR overexpression correlates with ↓cell proliferation, migration, and invasion ↓ NF-κB Signaling Pathway |
Xia et al. [29] | Case control study | 40 endometrial carcinoma samples and 40 controls | CFTR overexpression But CFTR inhibition associated with increased cell proliferation through ↓ (miR)-125b |
Xie et al. [30] | In vivo In vitro | Prostate cancer samples and cell lines | CFTR is downregulated CFTR tumor suppressor through miR-193b inhibition on uPA |
Tu et al. [31] | Case control study | 225 nasopharyngeal carcinoma tissue samples | CFTR is downregulated and correlate with advanced stage, poor prognosis and metastasis |
Zhong et al. [32] | In vitro | 153 human glioblastoma cell lines | Lower CFTR correlate with poor prognosis CFTR potentiators reduces cell proliferation through JAK2/STAT3 inhibition |
In vitro | Adenocarcinoma lung cancer cell lines A549 | CFTR overexpression acts as a tumor suppressor | |
Yang et al. [35] | Case control study In vitro | 138 patients with acute Leukemia 50 normal human samples | CFTR overexpression in acute lymphoblastic leukemia CFTR inhibits PP2A phosphatase antitumoral activity CFTR inhibitors reduces tumor growth |