Table 4 Summary of main studies about CFTR and reproductive system
From: Cystic fibrosis transmembrane conductance regulator (CFTR): beyond cystic fibrosis
Authors | Setting | Sample size | Major findings |
|---|---|---|---|
Yu et al. [66] | Meta-analysis | 38 studies 2744 individuals | 28% of men with CBAVD had only one CFTR mutation |
Chen et al. [69] | Ovarian follicles from rat PCOS model and control | CFTR is downregulated in PCOS and affects/impairs FSH-mediated granulosa cell proliferation in follicles | |
Zhang et al. [70] | Mice CFTR knock-out model | Possible role of CFTR in regulating blood pressure |