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Table 3 Distribution of studied groups according to RAGE (− 429 T > C and − 374 T > A) and Gly82/Ser: shows a significant difference between HT cases and control regarding distribution of single nucleotide polymorphism (SNP) of -427 T>C gene and shows nonsignificant differences regarding -347T>A and Gly 82 ser.

From: Receptor of advanced glycation end product (RAGE) polymorphism and oxidative status in Hashimoto’s thyroiditis in Egyptian female patients: case control study

Parameter

Cases group N = 80

Control group N = 80

P value

OR

RAGE − 429 T > C

TT

66(82.5%)

74(92.5%)

0.04* (S)

1

TC

10(12.5%)

6(7.5%)

1.86 (0.414–8.428)

CC

4(5%)

0 (0%)

5.5 (0.259–120.8)

RAGE − 374 T > A

TT

42 (52.5%)

22 (27.5%)

0.2 (NS)

1

TA

20(25%)

38(47.5%)

0.27 (0.095–0.793)

AA

18(22.5%)

20 (25%)

0.47 (0.147–1.5)

Gly82 /Ser82 RAGE

Gly82/Gly

72(90%)

76(95%)

0.5(NS)

1

Gly82/Ser

4(5%)

4(5%)

1.05 (0.14–7.8)

Ser82/Ser

4(5%)

0 (0%)

0.52 (0.009–4.2)

  1. RAGE Receptor of advanced glycation, OR ODDS RATIO
  2. S*: significant, NS: Non significant