Role of microRNAs in regulation of WNT signaling pathway in urothelial and prostate cancers

Montazer, Mehdi; Taghehchian, Negin; Mojarrad, Majid; Moghbeli, Meysam

doi:10.1186/s43042-022-00315-8

Egyptian Journal of Medical Human Genetics

Table 1 All of the microRNAs associated with regulation of WNT signaling in prostate and bladder cancers

From: Role of microRNAs in regulation of WNT signaling pathway in urothelial and prostate cancers

Study	Year	Gene	Country	Sample	Target	Results	Clinical application
Prostate cancer
Wang [55]	2018	miR-182	China	25 patients 2 cell lines	GSK3β, APC, CK1, and Axin	MiR-182 promoted WNT pathway through targeting of WNT destruction complex components including APC, Axin, CK1, and GSK-3β	Diagnosis
Ren [57]	2016	miR-613	China	3 cell lines	FZD7	MiR-613 up regulation inhibited the cell proliferation and invasion by FZD7/WNT signaling suppression	Diagnosis
Liang [63]	2016	miR-1297	China	20 patients 5 cell lines	AEG1	MiR-1297 suppressed PCa cell proliferation and invasion through AEG-1 targeting	Diagnosis
Zhong [65]	2017	miR-1271	China	20 patients 5 cell lines	DIXDC1	MiR-1271 over expression suppressed tumor cell proliferation and invasion through DIXDC1 targeting	Diagnosis
Zhao [59]	2014	miR-26a	China	20 patients 6 cell lines	WNT5A	MiR-26a inhibited PCa progression and in vivo growth through WNT5a suppression	Diagnosis
Fu [69]	2018	miR-454	China	20 patients 5 cell lines	NDRG2	There was a significant inverse correlation between NDRG2 and miR-454 expressions	Diagnosis
Ueno [70]	2013	miR-183	USA	31 patients 4 cell lines	DKK3	MiR-183 activates the WNT pathway via DKK3 and SMAD4 targeting. There was an inverse correlation between the miR-183 expression and overall survival	Diagnosis and prognosis
Guan [72]	2017	miR-744	China	10 patients 3 cell lines	SFRP1, GSK3β, TLE3, and NKD1	MiR-744 promoted cell proliferation and migration through down regulation of SFRP1, GSK3β, and NDK. There was an inverse correlation between the miR-744 expression and overall survival	Diagnosis and prognosis
Song [79]	2018	miR-1301-3p	China	8 patients 6 cell lines	GSK3β and SFRP1	MiR-1301-3p promoted the PCa stem cells through GSK3β and SFRP1 targeting	Diagnosis
Hsieh [80]	2013	miR-320	Taiwan	10 patients 7 cell lines	CTNNB1	MiR-320 inhibited the β-catenin and self-renewal ability	Diagnosis
Yu [81]	2018	miR-138	China	4 cell lines	CTNNB1	MiR-138 inhibited the β-catenin to maintain PCa cell epithelial status	Diagnosis
Siu [86]	2017	miR-1	Taiwan	111 patients 6 cell lines	TCF7	AR inhibited WNT signaling via miR-1-mediated suppression of TCF7	Diagnosis
Chen [92]	2015	miR-34a	Taiwan	24 patients 2 cell lines	TCF7	MiR-34a was an inhibitor of WNT signaling through TCF7 targeting. There was a direct correlation between the miR-34a expression and overall survival	Diagnosis and prognosis
Li [93]	2017	miR-432	China	? patients 1 cell line	TRIM29 and PYGO2	MiR-432 inactivated the WNT pathway through TRIM29 and PYGO2 targeting	Diagnosis
Liang [96]	2015	miR-34a	China	5 cell lines	LEF1	MiR-34a regulated the EMT process through LEF1 targeting	Diagnosis
Fu [99]	2019	miR-653-5p	China	5 cell lines	SOX30	There was an inverse correlation between SOX30 and miR-653-5p	Diagnosis
Li [102]	2016	miR-218	China	58 patients 2 cell lines	LGR4	MiR-218 suppressed PCa cell proliferation and invasion via LGR4 targeting	Diagnosis
Ren [105]	2018	miR-520b	China	25 patients 4 cell lines	CAPN4	The miR-520b inhibited the PCa cells invasion via CAPN4 targeting	Diagnosis
Cui [109]	2019	miR-15a-3p	China	35 patients 5 cell lines	SLC39A7	MiR-15a-3p inhibited the WNT signaling via SLC39A7 targeting	Diagnosis
Du [111]	2019	miR-601	China	87 patients 1 cell line	KRT5	MiR-601 down regulation inhibited the prostate cancer stem cells (PCSCs) proliferation and invasion through KRT5 induction and WNT signaling suppression	Diagnosis
Bladder cancer
Chen [115]	2018	miR-374a	China	3 cell lines	WNT5A	MiR-374a can be introduced as an inhibitor of aggressive tumor through WNT5A targeting. There was a direct correlation between the miR-374a expression and overall survival	Diagnosis and prognosis
Cao [117]	2018	miR-129-5p	China	28 patients 2 cell lines	WNT5A	MiR-129-5p increased gemcitabine sensitivity in BCa cells through Wnt5a targeting	Diagnosis and prognosis
Huang [118]	2018	miR-370-3p	China	41 patients 4 cell lines	WNT7A	MiR-370-3p/Wnt7a axis regulated UBC invasion via canonical WNT signaling. There was an inverse correlation between the miR-370 expression and overall survival	Diagnosis and prognosis
Tian [121]	2019	miR-621	China	50 patients 3 cell lines	TRIM29	MiR-621 suppressed the BC cell proliferation and metastasis through TRIM29 targeting. There was an inverse correlation between the miR-621 expression and overall survival	Diagnosis and prognosis
Hirata [122]	2012	miR-1826	USA	19 patients 4 cell lines	CTNNB1	MiR-1826 functions as a tumor suppressor through CTNNB1	Diagnosis
Zhang [123]	2018	miR-3619-5p	China	33 patients 4 cell lines	CTNNB1	MiR-3619 had an important role during BCa progression and metastasis through β-catenin targeting. There was a direct correlation between the miR-3619 expression and overall survival	Diagnosis and prognosis
Dong [124]	2018	miR-9	China	38 patients 3 cell lines	GSK3β	There was a significant converse association between the miR-9 and GSK-3β expressions	Diagnosis
Chen [125]	2018	miR-183	China	? patients 3 cell lines	AXIN2	MiR-183 activated the WNT signaling via AXIN2 suppression	Diagnosis
Xie [129]	2019	miR-532-5p	China	35 patients 3 cell lines	HMGB3	MiR-532-5p suppressed the BCa cell proliferation and invasion through HMGB3 targeting	Diagnosis
Guo (131)	2013	miR-144	China	23 patients 5 cell lines	EZH2	MiR-144 down regulation resulted in WNT signaling activation and BCa cell proliferation by EZH2 suppression	Diagnosis

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