Clinical implications of PON1 (rs662) and TNF-α (rs1799964) genes polymorphism in patients with coronary artery disease

Egyptian Journal of Medical Human Genetics

Table 2 The genotype, allele frequencies of PON1 (rs662) and TNF α (rs1799964) genes and their statistical analysis among CAD cases and controls

PON1 (rs662)		N	Control (155)	N	CAD (175)	OR	95% CI	^χ2	p values	Bonferroni-corrected p values	Power
PON1 (rs662)		N	Frequency (%)	N	Frequency (%)	OR	95% CI	^χ2	p values	Bonferroni-corrected p values	Power
Genotype	QQ	93	60.00	64	36.57	0.384	(0.25—0.60)	18.09	< 0.001	< 0.001	0.977
	QR	60	38.71	88	50.29	1.601	0.40—0.97	4.45	0.035	0.105	0.927
	RR	2	1.29	23	13.14	11.576	2.68—49.96	16.49	< 0.001	< 0.001	0.989
Allele	Q	246	79.35	216	61.71	0.419	0.30—0.59	24.36	< 0.001	< 0.001	0.987
Allele	R	64	20.65	134	38.29	2.384	1.68—3.38	24.36	< 0.001	< 0.001	0.987

TNF α (rs1799964)		N	Control (155)	N	CAD (175)	OR	95% CI	^χ2	p values	Bonferroni-corrected p values	Power
TNF α (rs1799964)		N	Frequency (%)	N	Frequency (%)	OR	95% CI	^χ2	p values	Bonferroni-corrected p values	Power
Genotype	CC	5	3.23	8	4.57	1.437	0.46—4.49	0.39	0.531	1.000	0.859
	CT	72	46.45	88	50.29	1.166	0.76—1.80	0.48	0.487	1.000	0.856
	TT	78	50.32	79	45.14	0.812	0.53—1.25	0.88	0.347	1.000	0.895
Allele	C	82	26.45	104	29.71	1.175	0.84—1.65	0.86	0.352	0.705	0.842
Allele	T	228	73.55	246	70.29	0.851	0.60—1.20	0.86	0.352	0.705	0.842

*N = number of subjects, OR = Odd ratio, CI = confidence interval, P = p-value, χ² = Chi-square test