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Fig. 4 | Egyptian Journal of Medical Human Genetics

Fig. 4

From: Generation of muscle progenitors from human-induced pluripotent stem cells

Fig. 4

Givinostat induce higher expression of skeletal myogenic genes: Skeletal muscle genes included Meox1, Meox2, Tcf15, Pax3, Pax7, MyoD1, dystrophin, myogenin, Myh2, Myh6, Tbx1, Mesp1, desmin and β-catenin. GIV increased upregulation of skeletal myogenic genes (Real Time PCR-analysis) in skeletal iPSCs (hiPSC- SKM) at first 4 days and further increased after 8 days versus control (A). Skeletal maturity genes were followed up at day 14 and Day 21 with normalized to day 8 (B). Values are mean ± SE; n = 3; P-value < 0.05, * P-value = 0.01, ** P-value = 0.001, # P-value = 0.0001 are significant

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