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Egyptian Journal of Medical Human Genetics
Fig. 1 | Egyptian Journal of Medical Human Genetics

Fig. 1

From: Influence of CYP2D6, CYP2C19 and CYP3A5 polymorphisms on plasma levels of tamoxifen metabolites in Algerian women with ER+ breast cancer

Fig. 1

Tamoxifen metabolism pathway in humans [16]. CYP 2D6 is the major isoform responsible for the formation of 4-hydroxytamoxifen and CYP3A4/5 is the major isoform responsible for the formation of N-desmethyltamoxifen, whereas the generation of Endoxifen is predominantly catalyzed by CYP2D6. Other CYP isoforms, including CYP2C19, CYP2C9, and CYP2B6, appear to play less important roles in Tamoxifen metabolism in vitro at therapeutically relevant concentrations

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