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Table 2 Correlation of SALL4 and HIWI genes expression with clinicopathological features of the patients

From: Co-overexpression of self-renewal markers SALL4 and HIWI is correlated with depth of tumor invasion and metastasis in colorectal cancer

Factors

Number %

 

HIWI

SALL4

P value

   

Normal/Under

Overexpression

Normal/Under

Overexpression

 

Sex

Female

20 (43.5)

14

6

2

18

0.354

 

Male

26 (56.5)

16

10

4

22

 

Tumor location

Proximal

13 (28.3)

8

5

2

11

0.124

 

Distal

33 (71.7)

22

11

4

29

 

Grade of differentiation

WD

29 (63)

19

10

4

25

0.004*

 

MD

16 (43.8)

10

6

1

15

 
 

PD

1 (2.2)

1

0

1

0

 

Depth of invasion

T1,2

8 (17.4)

3

5

0

8

0.031*

 

T3,4

38 (82.6)

27

11

6

32

 

Lymph node metastasis

N0

33 (71.7)

23

10

5

28

0.050*

 

N1

9 (19.6)

4

5

0

9

 
 

N2

4 (8.7)

3

1

1

3

 

Stage of progression

I/II

34 (73.9)

23

11

2

29

0.362

 

III/IV

12 (26.1)

7

5

1

4

 
  1. *statistically significant WD well differentiated, MD moderately differentiated, PD poorly differentiated, T depth of tumor invasion, N node metastasis. “Log 2 fold change > 2” was considered as overexpression, while log 2 fold change < − 2 was measured as underexpression. The range of log 2 fold change between 2 and -2 was considered as normal (unchanged) expression