Fig. 1From: Telomere attrition and inflammation: the chicken and the egg storyThe DNA fragments obtained after complete telomeric loss, are not G-rich, hence when released into cytoplasm activates cGAS/STING pathway. The fragmented DNA that enter endosomes tend to activate TLR9. Both cGAS/STING and TLR9 activate the NF-κB pathway and induce inflammationBack to article page