A genetic study of the association of six polymorphisms with rheumatoid arthritis in the Egyptian population

Egyptian Journal of Medical Human Genetics

Table 4 Previous studies on RA association

Gene	Population	No. of cases	No. of controls	Genotype	Allele	Association with RA	Reference
MIR146A	Egyptian (this study)	52	49	CG	C	Protective
	Chinese	126	102			No association	[11]
	Iranian	104	110			No association	[19]
	Polish	111	130			No association	[20]
	Caucasian and Asian	2660	4098			No association	[21]
	Han Chinese (Sichuan)	208	240			No association	[22]
	Egyptian female (Zagazig)	217	245			No association	[23]
	Greek	136	147			No association	[24]
	Chinese (Changzhou)	600	839			No association	[25]
MIR499, MIR499A	Egyptian (This Study)	52	49			No association
	Chinese (Jiangsu)	214	478			No association	[26]
	Han Chinese (Anhui)	386	576			No association	[27]
	Iranian	104	110	TC	C	Protective	[19]
	Caucasian and Asian	2660	4098	TC	C	Susceptible in Caucasian, No association in Asian	[21]
	Egyptian (Suez Canal)	100	100	TC	C	Susceptible	[7]
	Egyptian female (Zagazig)	217	245	TC	T	Susceptible	[23]
	Han Chinese (Sichuan)	208	240			No association	[22]
MTMR3	Egyptian (This Study)	52	49	CT	C	Susceptible
MIR155HG	Egyptian (This Study)	52	49	AT		Protective while excluded
MIR155HG	Egyptian (Zagazig)	100	100	AT	A	Susceptible	[28]
IRAK1	Egyptian (This Study)	52	49	CA		Susceptible while excluded
	Chinese (Jiangsu)	214	478	CA	A	Susceptible	[26]
	Han Chinese (Anhui)	386	576	CA	C	Susceptible	[27]
	Greek	136	147	CA	C	Susceptible	[24]
	Iranian	120	120			No association	[29]
PADI4	Egyptian (This Study)	52	49	CT		Susceptible while excluded
PADI4	Iranian	150	150	CT	T	Susceptible	[16]