Association of Interleukin 6 and Interleukin 8 genes polymorphisms with house dust mite-induced nasal-bronchial allergy in a sample of Indian patients

Egyptian Journal of Medical Human Genetics

Table 4 Association of IL 6 and IL 8 gene polymorphisms with the severity of HDM sensitization ( signifies p < 0.001, * signifies p < 0.0001 and values are significant)

Genotype and allele	Control (n = 110)	Moderate (n = 231)	Chi-square value	P value	Severe (n = 141)	Chi-square value	P value
IL 6
− 572					43
GG	50	59	19.58	< 0.0001***	76	6.879	0.0087**
GC	52	122			20
CC	8	52
Allele
G	152	240	18.88	< 0.0001***	162	6.169	0.0130*
C	68	226			116
− 597
GG	76	167	0.002	0.965	92	0.8841	0.3471
GA	34	56			46
AA	0	8			3
Allele
G	186	390	0.002	0.9651	230	0.7758	0.3748
A	34	72			52
IL 8
− 251	46	64			35
AA	55	119	11.42	0.0007***	76	12.43	0.0004***
AT	9	48			30
TT
Allele
A	147	247	10.9	0.001***	146	7.159	0.0075**
T	73	215			120
781
CC	56	136			65
CT	54	80	0.0478	0.8269	75	0.731	0.3926
TT	0	15			1
Allele
C	166	352			205
T	54	110	0.0442	0.8335	77	0.488	0.4848