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Fig. 2 | Egyptian Journal of Medical Human Genetics

Fig. 2

From: Pathway analysis of sepsis-induced changes gene expression

Fig. 2

Upstream regulators (A) filgrastim and (B) ESR1. Chemical drug filgrastim is predicted to be activated in sepsis with p-value = 1.36 x 10–7 and Z-score 4.170. (BESR1 is predicted to be activated in sepsis with P-value = 1.55 x 10–8 and Z-score = 4.064. Different shapes represent the molecular class of the protein. Red and green indicate down-regulation and up-regulation, respectively, while blue and orange indicate inhibition and activation, respectively. A solid line indicates a direct interaction, a dashed line indicates an indirect interaction, and a dotted line indicates inferred correlation from machine-based learning. An asterisk indicates that multiple identifiers in the dataset file map to a single gene or chemical in the Global Molecular Network

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