Table 1 Ingenuity pathway analysis uncovered the top 20 upstream regulators
From: Pathway analysis of sepsis-induced changes gene expression
Upstream regulator | Molecule type | Log2 ratio | p-value | Z score |
|---|---|---|---|---|
Filgrastim | Biologic drug | 1.36 × 10–7 | 4.170 | |
ESR1 | Ligand-dependent nuclear receptor | 1.55 × 10–8 | 4.064 | |
Fluticasone propionate | Chemical drug | 2.65 × 10–4 | 3.768 | |
SIRT1 | Transcription regulator | 0.121 | 2.22 × 10–3 | 3.666 |
PTPRR | Phosphatase | 0.034 | 7.07 × 10–3 | 3.561 |
Dexamethasone | Chemical drug | 4.60 × 10–9 | 3.SOl | |
5-fluorouracil | Chemical drug | 3.13 × 10–9 | 3.481 | |
IL1B | Cytokine | 0.237 | 1.77 × 10–2 | 3.211 |
Fulvestrant | Chemical drug | 3.47 × 10–4 | 3.141 | |
Levodopa | Chemical endogenous neurotransmitter | 9.64 × 10–4 | 3.030 | |
JUNB | Transcription regulator | − 0.066 | 5.20 × 10–3 | 3.023 |
Cdk | Group | 3.50 × 10–5 | 2.994 | |
Phenylephrine | Chemical drug | 1.00 × 100 | 2.804 | |
CXCL12 | Cytokine | 0.000 | 4.02 × 10–2 | 2.732 |
Cisplatin | Chemical drug | 2.14 × 10–5 | 2.686 | |
NOS2 | Enzyme | 1.39 × 10–1 | 2.661 | |
EFNA2 | Kinase | 0.013 | 4.82 × 10–1 | 2.646 |
TFE3 | Transcription regulator | − 0.059 | 1.12 × 10–1 | 2.621 |
Cerivastatin | Chemical drug | 2.63 × 10–1 | 2.620 | |
TRAP1 | Enzyme | − 0.101 | 6.68 × 10–4 | 2.618 |