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Table 8 Prediction of nsSNP deleteriousness by another different ranking scores

From: Mutational analysis of phospholipase C epsilon 1 gene in Egyptian children with steroid-resistant nephrotic syndrome

Mutation

FATHMM

SIFT

PROVEAN

SNPs&GO

PANTHER

Mutpred

Suspect

SNP analyzer

R1230H

0.23

tolerated

0.0

damaging

 − 4.128

deleterious

0.683

Disease

0.554 Probably damaging

0.637

Gain of ubquitina-tion

34%

benign

Disease

E1393K

0.55

tolerated

0.04

damaging

 − 2.662

deleterious

0.194

Neutral

0.220

Probably damaging

0.570

Gain of methylation

23%

benign

Disease