Egyptian Journal of Medical Human Genetics

Table 5 Relationship of the genetic variant with clinical characteristics of the population in studied groups

From: Association of the ANGPTL3 gene polymorphisms and haplotypes with cardiovascular diseases in Birjand longitudinal aging study (BLAS)

Polymorphisms	CVD (N = 129)				No CVD (N = 231)
Lipid profile (mg/dl)	CC	CG	GG	P	CC	CG	GG	P
rs1748195
Cho	174.50 (52.00)	175.00 (40.00)	158.00 (83.00)	0.653	201.00 ± 40.32	202.02 ± 36.62	182.89 ± 47.95	0.079
TG	140.50 (79.00)	130.00 (87.00)	127.00 (60.00)	0.266	148.00 (66.00)	148.00 (66.00)	138.00 (111.00)	0.627
HDL	43.40 ± 4.41	44.94 ± 3.98	44.24 ± 4.59	0.215	46.00 (6.00)	45.50 (9.00)	46.00 (7.00)	0.493
LDL	94.50 (49.00)	101.00 (39.00)	94.00 (68.00)	0.758	123.61 ± 34.32^a	124.10 ± 33.47	105.81 ± 39.61^b	0.042
Apo-A1	109.82 ± 19.18	116.68 ± 11.90	104.91 ± 18.23	0.138	117.00 (17.5)	117.00 (25.00)	115.00 (21.00)	0.950
Apo-B	86.00 (35.30)	88.00 (34.30)	80.00 (50.00)	0.409	97.65 ± 27.74	91.76 ± 25.72	90.56 ± 24.19	0.226

Polymorphisms	CVD (N = 129)				No CVD (N = 231)
Lipid profile (mg/dl)	AA	AC	CC	P	AA	AC	CC	P
rs10789117
Cho	181.00 (54.00)	162.00 (50.00)	180.00 (76.00)	0.165	193.96 ± 40.36^a	207.64 ± 37.95^b	188.96 ± 44.32	0.021
TG	134.00 (75.00)	137.00 (84.00)	128.50 (95.00)	0.947	146.00 (55.00)	148.00 (86.00)	148.00 (56.00)	0.281
HDL	45.00 (6.00)	43.50 (5.00)	45.00 (6.00)	0.340	45.00 (7.00)^a	47.00 (7.00)	47.00 (7.00)^b	0.040
LDL	103.00 (47.00)	93.00 (46.00)	106.50 (53.00)	0.102	117.64 ± 35.40	128.00 ± 33.05	114.46 ± 38.17	0.058
Apo-A1	116.00 (20.00)	107.00 (27.00)	105.00 (16.50)	0.564	115.00 (18.50)	118.00 (20.00)	116.50 (25.30)	0.130
Apo-B	86.00 (40.00)	81.00 (22.00)	92.00 (31.00)	0.325	93.27 ± 26.92	98.10 ± 24.82	86.32 ± 31.27	0.122

Polymorphisms	CVD (N = 129)				No CVD (N = 231)
Lipid profile (mg/dl)	CC	CT	TT	P	CC	CT	TT	P
rs11207997
Cho	177.26 ± 39.94	178.32 ± 43.16	160.33 ± 43.51	0.482	197.42 ± 41.66	199.86 ± 40.18	204.25 ± 25.93	0.891
TG	128.00 (89.00)	138.00 (84.00)	138.00 (75.00)	0.724	149.00 (76.00)	148.00 (60.00)	136.50 (232.00)	0.754
HDL	44.74 ± 4.32	44.04 ± 4.52	43.67 ± 2.87	0.718	45.00 (8.00)	46.00 (6.00)	40.00 (13.00)	0.164
LDL	102.00 (50.00)	96.00 (47.00)	74.00 (60.00)	0.379	122.00 (50.00)	120.50 (47.00)	131.00 (14.00)	0.836
Apo-A1	116.00 (26.30)	115.00 (18.50)	104.50 (25.80)	0.676	116.00 (23.30)	117.00 (21.00)	123.50 (12.00)	0.200
Apo-B	88.00 (43.50)	86.00 (26.50)	89.50 (49.80)	0.863	94.50 (37.50)	95.50 (33.80)	75.50(25.50)	0.250

Cho Cholesterol; TG Triglyceride; HDL-C High-density lipoprotein cholesterol; LDL Low-density lipoprotein
Note: regarding rs1748195 letter “a” means significantly difference between CC and CG and letter “b” means significantly difference between CG and GG. Moreover, regarding rs10789117 letter “a” means significantly difference between AA and AC and letter “b” means significantly difference between AC and CC

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