Explore the distribution of (rs35742686, rs3892097 and rs1065852) genetic polymorphisms of cytochrome P4502D6 gene in the Moroccan population

Egyptian Journal of Medical Human Genetics

Table 5 Distribution of CYP2D6 allele frequencies in the Moroccan population compared to other worldwide populations

Population	No of Individuals	Non-functional				Reduced		References
Population	No of Individuals	*3	P-value	*4	P-value	*10	P-value	References
Moroccan	321	11.8	–	10.5	–	7.7	–	Present study
Tunisian	230	–	–	15.2	0.04	–	–	[30]
Egyptian	29	–	–	13.8	0.34	–	–	[31]
Syrian	51	0	0.00	9.8	0.93	2.94	0.11	[32]
South African	99	0	0.00	7.07	0.33	2.53	0.00	[33]
Ghanaian	193	0	0.00	7	0.20	3.1	0.006	[34]
Ethiopian	69	0	0.00	5.9	0.19	8	0.85	[35]
Venda	81	0	0.00	3	0.01	12	0.11	[36]
Spanish	133	0.75	0.00	11.65	0.37	0.38	0.00	[37]
Portuguese	1138	1.4	0.00	15.6	0.00	2.5	0.00	[38]
French	672	1.8	0.00	17.2	0.00	1.5	0.00	[39]
Italian	360	0.7	0.00	15.3	0.00	–	–	[40]
German	589	2.04	0.00	21	0.00	1.53	0.00	[41]
Polish	145	2.1	0.00	23	0.00	–	–	[42]
Finnish	857	2.6	0.00	10.7	0.43	12.7	0.00	[18]
British	94	3.3	0.00	24.2	0.00	0.5	0.007	[43]
Greek	283	2.3	0.00	17.8	0.00	–	–	[44]
Turkish	200	6	0.002	10	0.793	26	0.00	[45]
Iranian	100	0.5	0.00	9	0.539	–	–	[17]
	100	–	–	12.5	0.24	9	0.79	[46]
Brazilian	95	9.4	0.12	13.1	0.57	–	–	[47]
	179	1.5	0.00	6.32	0.12	4.02	4.40	[48]
Indian	83	0	0.00	8	0.30	15	0.00	[49]
Chinese	223	0	0.00	0.2	0.00	51.3	0.00	[50]
Japanese	98	0	0.00	0.5	0.00	40.8	0.00	[51]