Table 3 Association of IL-10, IL-1ß, and TNF-α polymorphisms with risk of periodontitis
Allele/Genotype | Patients N (%) | Controls N (%) | P value* | Odds ratio (95% CI) |
|---|---|---|---|---|
IL-10 ─ 592 C/A | ||||
Alleles | ||||
C | 102 (59%) | 141 (79%) | ||
A | 72 (41%) | 37 (21%) | < 0.001 | 2.69(1.68–4.31) |
Genotype | ||||
CC | 28 (32%) | 53 (60%) | < 0.001 | 0.322(0.174–0.598) |
CA | 46 (53%) | 35 (39%) | 0.071 | 1.731(0.952–3.149) |
AA | 13 (15%) | 1 (1%) | 0.011 | 9.486(1.204–74.727) |
IL-10 ─ 819 C/T | ||||
|---|---|---|---|---|
Alleles | ||||
C | 85 (49%) | 125 (70%) | ||
T | 89 (51%) | 53 (30%) | < 0.001 | 2.47(1.594–3.826) |
Genotypes | ||||
CC | 20 (23%) | 45 (51%) | < 0.001 | 0.292(0.152–0.559) |
CT | 45 (52%) | 35 (39%) | 0.099 | 1.653(0.909–3.006) |
TT | 22 (25%) | 9 (10%) | 0.008 | 3.009(1.297–6.981) |
IL-1ß + 3954 C/T | ||||
|---|---|---|---|---|
Alleles | ||||
C | 144 (83%) | 171 (96%) | ||
T | 30 (17%) | 7 (4%) | < 0.001 | 5.089(2.171–11.931) |
Genotypes | ||||
CC | 62 (71%) | 82 (92%) | < 0.001 | 0.212(0.086–0.521) |
CT | 20 (23%) | 7 (8%) | 0.005 | 3.497(1.395–8.768) |
TT | 5 (6%) | 0 (0%) | 0.560✝ | - |
TNF-α ─ 308 G/A | ||||
|---|---|---|---|---|
Alleles | ||||
A | 136 (78%) | 152 (85%) | ||
G | 38 (22%) | 26 (15%) | 0.079 | 1.633(0.943–2.831) |
Genotypes | ||||
GG | 7 (8%) | 4 (5%) | 0.330 | 1.859(0.524–6.593) |
GA | 24 (28%) | 18 (20%) | 0.252 | 1.503(0.747–3.023) |
AA | 56 (64%) | 67 (75%) | 0.115 | 0.593(0.309–1.138) |
TNF-α ─ 857 G/A | ||||
|---|---|---|---|---|
Alleles | ||||
G | 66 (38%) | 50 (28%) | ||
A | 108 (62%) | 128 (72%) | 0.050 | 0.639(0.408–1) |
Genotypes | ||||
GG | 13 (15%) | 10 (11%) | 0.466 | 1.388(0.574–3.357) |
GA | 40 (46%) | 30 (34%) | 0.096 | 1.674(0.91–3.077) |
AA | 34 (39%) | 49 (55%) | 0.034 | 0.524(0.287–0.954) |