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Table 2 Anthropometric and laboratory parameters of all participants based on subgroup analysis by CAD and gender

From: Association of methylation status of ABCA1/G1 genes with the risk of coronary artery disease

Variables

Control (40)

CAD (70)

P

Men (75)

Women (35)

p

Age (year)

51.63ā€‰Ā±ā€‰10.53

54.84ā€‰Ā±ā€‰8.18

0.100

52.67ā€‰Ā±ā€‰9.22

55.83ā€‰Ā±ā€‰8.87

0.093

Gender (M/F)

23/17

52/18

0.069

ā€“

ā€“

ā€“

Male, n (%)

23 (57.5)

52 (74.3)

ā€“

ā€“

ā€“

ā€“

Female, n (%)

17 (42.5)

18 (25.7)

ā€“

ā€“

ā€“

ā€“

BMI (kg/m2)

25.44ā€‰Ā±ā€‰5.09

25.06ā€‰Ā±ā€‰4.20

0.674

24.14ā€‰Ā±ā€‰4.32

27.45ā€‰Ā±ā€‰4.17

<ā€‰0.001

Systolic blood pressure (mmHg)

127.22ā€‰Ā±ā€‰22.32

136.21ā€‰Ā±ā€‰20.80

0.036

128.71ā€‰Ā±ā€‰18.13

142.03ā€‰Ā±ā€‰25.88

0.008

Diastolic blood pressure (mmHg)

78.63ā€‰Ā±ā€‰11.36

82.34ā€‰Ā±ā€‰10.12

0.079

80.53ā€‰Ā±ā€‰10.19

81.97ā€‰Ā±ā€‰11.77

0.513

Blood pressure history, n (%)

15 (37.5)

30 (42.9)

0.583

26 (34.7)

19 (40.9)

0.51

Smoking, n (%)

20 (50)

45 (64.3)

0.143

50 (66.7)

15 (42.9)

0.018

Aspirin medication, n (%)

34 (85)

58 (82.9)

0.896

61 (81.3)

31 (88.6)

0.339

Statin medication, n (%)

28 (70)

51 (72.9)

0.749

51 (68)

28 (80)

0.193

ABCA1 methylation, n (%)

24 (60)

56 (80)

0.023

50 (66.7)

30 (85.7)

0.037

ABCG1 methylation, n (%)

24 (60)

29 (41.4)

0.061

33 (44)

20 (57.1)

0.199

TG (mg/dl)

102.50 (80.75ā€“164.50)

139.50 (98.00ā€“178.50)

0.278

132 (91ā€“180)

134 (95ā€“160)

0.760

Total cholesterol (mg/dl)

156.10ā€‰Ā±ā€‰42.55

157.50ā€‰Ā±ā€‰37.96

0.895

153.93ā€‰Ā±ā€‰39.86

163.54ā€‰Ā±ā€‰38.45

0.236

HDL-C (mg/dl)

41.82ā€‰Ā±ā€‰10.32

41.66ā€‰Ā±ā€‰12.64

0.946

40.35ā€‰Ā±ā€‰11.91

44.63ā€‰Ā±ā€‰11.16

0.077

LDL-C (mg/dl)

85.96ā€‰Ā±ā€‰38.72

84.94ā€‰Ā±ā€‰39.79

0.897

85.42ā€‰Ā±ā€‰38.73

85.07ā€‰Ā±ā€‰40.84

0.966

ApoA1 (mg/dl)

133.10ā€‰Ā±ā€‰25.25

129.38ā€‰Ā±ā€‰25.16

0.457

127.80ā€‰Ā±ā€‰25.55

137.01ā€‰Ā±ā€‰23.36

0.073

ApoB (mg/dl)

79.88ā€‰Ā±ā€‰28.35

85.31ā€‰Ā±ā€‰26.81

0.320

82.43ā€‰Ā±ā€‰25.10

85.28ā€‰Ā±ā€‰32.01

0.644

ApoB/ApoA1

0.62ā€‰Ā±ā€‰0.26

0.69ā€‰Ā±ā€‰0.26

0.207

0.67ā€‰Ā±ā€‰0.23

0.65ā€‰Ā±ā€‰0.31

0.698

  1. Continuous variables with normal and non-normal distribution are presented as meanā€‰Ā±ā€‰SD and median (IQR), respectively. Independent Student's t test was performed for normally distributed data and Mannā€“Whitney U test for non-normally distributed data. Categorical variables are described as number (percentage) using Chi-square test
  2. CAD coronary artery disease, BMI body mass index, ABCA1 ATP-binding cassette transporters A1, ABCG1 ATP-binding cassette transporters G1, TG triglyceride, HDL-C high-density lipoprotein-cholesterol, LDL-C low-density lipoprotein-cholesterol, ApoA1 apolipoprotein A1, ApoB apolipoprotein B