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Egyptian Journal of Medical Human Genetics
Fig. 3 | Egyptian Journal of Medical Human Genetics

Fig. 3

From: Genome-wide landscape of RNA-binding protein (RBP) networks as potential molecular regulators of psychiatric co-morbidities: a computational analysis

Fig. 3

Number of RBPs potentially driving differential gene expression in diseased post-mortem human brain samples. Differentially expressed genes within the transcriptome datasets of post-mortem human brain samples (schizophrenia/SCZ, major depressive disorder/MDD, and bipolar disorder/BD) were analysed to identify the potential RBPs driving gene expression changes in disease conditions. Thirteen RBPs (CPEB3/CPEB4, DAZAP1, ELAVL1/ELAVL3, hnRNPC, hnRNPCL1, PCBP4/PCBP1/PCBP3, PCBP4/PCBP3, PTBP1/PTBP2/ROD1, RBMS2/RBMS1, SF3B4, TARDBP, U2AF2, and YBX2/CSDA) were found to be involved in the three disorders considered, indicating their potential central roles in multiple disorders

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