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Table 2 Differential gene expression and RBP analysis of transcriptome datasets from post-mortem human brain samples

From: Genome-wide landscape of RNA-binding protein (RBP) networks as potential molecular regulators of psychiatric co-morbidities: a computational analysis

S. No

Dataset [Reference]

Disorders

Sample size

Brain regions

No. of DEGs (control vs. diseased brain samples)

RBPs influencing differential expression

1

GSE53987 [44]

MDD, BD, and SCZ

BD:18–19

Control:17–19; SCZ:15–18

Hippocampus, PFCa, and striatum

MDD and BD: none; SCZ: 4835 (hippocampus), 19 (PFC)

NA

2

GSE92538 [45]

MDD, BD, and SCZ

BD: 12

Control: 56

MDD: 29

SCZ:31

DLPFCb

BD: none; SCZ: 681; MDD: 1760

MDD: 97

SCZ: 94

3

GSE120340 [46]

BD and SCZ

BD with psychosis: 6

BD without psychosis: 4

SCZ: 10

Control: 10

DLPFCb

None

NA

4

GSE35977 [47]

BD, depression, and SCZ

BD: 45

Control: 50

Depression: 14

SCZ: 51

Parietal cortex

BD and depression: none; SCZ: 38

NA

5

GSE35974 [48]

BD, depression, and SCZ

BD: 37

Control: 50

Depression: 13

SCZ: 44

Cerebellum

BD: 953; depression: 6; SCZ: 373

BD: 15

SCZ: 1

6

GSE12679 [49]

BD and SCZ

BD: 5

Control: 5–6

SCZ: 11

Endothelial cells/neurons isolated from post-mortem DLPFCb

None

NA

  1. aPrefrontal cortex
  2. bDorsolateral prefrontal cortex