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Egyptian Journal of Medical Human Genetics

Table 3 Correlation of oxidative stress markers with MTHFR polymorphism in cases and controls

From: Association of MTHFR C677T polymorphism with risk of preterm birth in Indian mothers: a case–control study

ROS markers

Control (full-term mothers) N = 100

Cases (PTB mothers) N = 100

CC

CT

TT

CC

CT

TT

SOD

25.74 ± 0.24

22.53 ± 0.23####

00####

23.77 ± 0.14***

20.41 ± 0.25 ****####

18.67 ± 1.22 ***####

CAT

11.26 ± 0.27

10.39 ± 0.36####

00####

8.139 ± 0.25****

9.076 ± 0.36*####

6.457 ± 0.58***####

LPO

8.652 ± 0.20

8.858 ± 0.26####

00####

10.06 ± 0.30 ***

11.07 ± 0.15 ****##

12.05 ± 0.34 ****##

Total protein

29.11 ± 0.29

30.14 ± 0.34####

00####

24.11 ± 0.35 ****

25.17 ± 0.32 ****ns

24.37 ± 1.28 ****ns

  1. ROS—reactive oxygen species, SOD—superoxide dismutase, CAT—catalase, LPO—lipid peroxidation. Results are expressed as the mean value ± SEM. Data were analysed by unpaired t test and one-way ANOVA
  2. *Comparison between the group: Control vs Cases, CC vs CC, CT vs CT, TT vs TT: *p < 0.05; ***p < 0.001; ****p < 0.0001
  3. #Comparison within each group
  4. Control: CC vs CT vs TT: ####p < 0.0001
  5. Cases: CC vs CT vs TT: ##p < 0.01; ####p < 0.0001; ns—non-significant
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