Fig. 1
From: The role of HLA genotypes in understanding the pathogenesis of severe COVID-19
SARS-CoV-2 antigen presentation pathway through MHC-I molecules. Cells infected with SARS-CoV-2 produce various isoforms of endoplasmic reticulum aminopeptidase 2 (ERAP2) genes dimerized with either ERAP2-wild type (wt) or ERAP1-wt which can be presented on cells and recognized by specific CD8 + cytotoxic T lymphocytes (CTL). ER: endoplasmic reticulum; TAP: transporter associated with antigen processing [36]. Created with BioRender.com