Egyptian Journal of Medical Human Genetics

Table 4 rs2740348 G/C genotypes frequencies and ITP characteristics

From: A case–control study of single-nucleotide variants in microRNA biogenesis genes (AGO1 and GEMIN4) in people with primary immune thrombocytopenia

	GEMIN4 rs2740348 G/C genotype				p-value *
	GC		CC
	N (8)	%	N (92)	%
Sex
Male	1	12.5	12	13.04	0.965
Female	7	87.5	80	86.96
Phase
Newly diagnosed	4	50	27	29.35	0.298
Persistent	0	0	16	17.39
Chronic	4	50	49	53.26
Cutaneous bleeding
Petechia and Purpura	8	100	90	97.83	0.674
Ecchymosis	4	50	39	42.39	0.677
Non-cutaneous bleeding
Epistaxis	4	50	36	39.13	0.547
Vaginal Bleeding	2	25	31	33.7	0.616
Bleeding/ gums	3	37	35	38.04	0.976
Grade of bleeding
1	2	25	36	39.13	0.612
2	2	25	13	14.13
3	4	50	43	46.74
Treatment modalities
Corticosteroid	8	100	69	75	0.107
Immunosuppressive	3	37.5	31	33.7	0.828
TPO agonist	0	0	3	3.26	0.604
Splenectomy	0	0	10	10.87	0.326
Response
No response	0	0	5	5.34	0.499
Response	8	100	87	94.57
Death	0	0	1	1.09	0.767

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