Table 1 HOTAIR expression level and function in different cancers
From: Mutual interaction of lncRNAs and epigenetics: focusing on cancer
Cancer | Expression level | Function | Refs |
|---|---|---|---|
Glioma | Upregulated | Mediating HOXA9 actions | [47] |
Osteosarcoma | Upregulated | _Increasing DNMT1 expression _Hypermethylation of CDKN2A promoter _miR-126 repression | [74] |
SCLC | Upregulated | _DNMT1 and DNMT3b overexpression _Hypermethylation of the HOXA1 promoter region | [75] |
HCC | Upregulated | Recruiting EZH2 to the promoter of miR-122 | [102] |
GIST | Upregulated | _Hyper- or hypomethylating different CpG sites _recruiting the PRC2Â to these to CpG sites _Facilitating the interaction between DNMTs, EZH2, and PRC2 | [102] |