Table 2 Effect of DNA methylation on lncRNA expression
From: Mutual interaction of lncRNAs and epigenetics: focusing on cancer
lncRNA | Function | Expression level | cancer | Refs |
|---|---|---|---|---|
MEG3 | Interaction with p53 pathway | Downregulated | BC | [22] |
BLAT1 | Apoptosis‌ inhibition | Upregulated | BC | [23] |
LINC00460 | Promoting invasion and migration | Upregulated | CRC | [27] |
PVT1 | EMT and angiogenesis | Upregulated | Colon adenocarcinoma | [135] |
MEG3 | Regulation of ATP4B and miR-21 expression | Downregulated | GC | [34] |
SOX21-AS1 | Sequence-specific DNA binding of RNA polymerase II transcription factor, SOX2 regulation | Upregulated | Cervical cancer | [40] |
LINC00592 | Transcription and cell integrity | Upregulated | Cervical cancer | [41] |
AFAP1-AS1 | Upregulating AFAP1, promoting cell migration | Upregulated | NSCLC | [136] |
MEG3 | ceRNA for miR-9, regulating E-cadherin and FOXO1 | Downregulated | ESCC | [51] |
H19 | BCR-ABL-mediated leukemogenesis | Upregulated | CML | [137] |
MEG3 | Targeting miR147, sponging miR21 | Downregulated | CML | [58] |
Neat1 | Suppressing proliferation, migration, and invasion | Downregulated | AML | [61] |