Table 3 Genotype and allele prevalence of TP53 (rs1042522) polymorphism among studied groups using SNPstat software
TP53 (rs1042522) | Healthy (n = 100) No (%) | BC (n = 100) No (%) | Odds ratio (95% CI) | P-value | Familial BC (n = 50) No (%) | Non-familial BC (n = 50) No (%) | Odds ratio (95% CI) | P-value |
|---|---|---|---|---|---|---|---|---|
CC (Pro/Pro) | 54 (54%) | 19 (19%) | 1.00 | Â | 25 (50%) | 17 (34%) | 1.00 | Â |
CG (Pro/Arg) | 38 (38%) | 39 (39%) | 0.34 (0.17–0.68) |  < 0.0001* | 17 (34%) | 22 (44%) | 1.9 (0.79–4.6) | 0.27 |
GG (Arg/Arg) | 8 (8%) | 42 (42%) | 0.07 (0.03–0.17) |  < 0.0001* | 8 (16%) | 11 (22%) | 2.02 (0.67–6.07) | 0.27 |
CG (Pro/Arg) + GG (Arg/Arg) | 46 (46%) | 81 (81%) | 0.2 (0.11–0.38) |  < 0.0001* | 25 (50%) | 33 (66%) | 1.48 (0.54–4.06) | 0.14 |
TP53 alleles | ||||||||
C | 146 (73%) | 77 (38%) | Â | 0.01* | 33 (33%) | 44 (44%) | Â | 0.16 |
G | 54 (27%) | 123 (62%) | Â | 67 (67%) | 56 (56%) | Â | ||