Table 5 Clinical and pathological characterization of non-familial BC patients with prevalence of TP53 rs1042522 genotypes carrying the high-risk allele [Pro/Arg (CG) and Arg/Arg (GG)]
Characteristic | Non-Familial BC [Pro/Pro (CC)] (N = 17) | Non-Familial BC [Pro/Arg (CG) and Arg/Arg (GG)] (N = 33) | P value | |
|---|---|---|---|---|
Tumor size [cm] | Â | Â | Â | |
Mean ± SD | 2.3 ± 1.7 | 2.6 ± 1.2 | 0.156a | |
Tumor grade | ||||
G1 | 2 (%) | 4 (%) | 0.783b | |
G2 | 10 (%) | 25 (%) | ||
G3 | 5 (%) | 4 (%) | ||
Axillary lymph node metastasis | ||||
Negative | 10 (%) | 18 (%) | 0.475b | |
Positive | 7 (%) | 15 (%) | ||
Lymphovascular invasion | ||||
Negative | 12 (%) | 26 (%) | 0.277b | |
Positive | 5 (%) | 7 (%) | ||
ER | ||||
Negative | 8 (%) | 14 (%) | 0.629b | |
Positive | 8 (%) | 16 (%) | ||
NA | 1 (%) | 3 (%) | ||
PR | ||||
Negative | 7 (%) | 9 (%) | 0.236b | |
Positive | 9 (%) | 21 (%) | ||
NA | 1 (%) | 3 (%) | ||
Her-2 | ||||
Negative | 6 (%) | 21 (%) | 0.349b | |
Positive | 10 (%) | 9 (%) | ||
NA | 1 (%) | 3 (%) | ||