Table 4 Association between MTHFR C677T variant and CHDs Risk across the selected cases
Author | El-Abd et al. | Kotby et al. | The current study | |||
|---|---|---|---|---|---|---|
CHDs population | Mixed* | Conotruncal heart defects | Mixed | |||
Models of inheritance | Cases N = 26 | Controls N = 18 | Cases N = 30 | Controls N = 30 | Cases N = 91 | Controls N = 95 |
CT + TT CC Dominant model | 19 7 | 5 13 | 18 12 | 10 20 | 49 42 | 40 55 |
OR [CI 95%] P value | 7.06 [1.83–27.15] 0.005 | 3.00 [1.05–8.60] 0.0410 | 1.60 [0.90–2.86] 0.1099 | |||
CT CC Heterozygote model | 12 7 | 5 13 | 14 12 | 8 20 | 41 42 | 34 55 |
OR[CI 95%] P value | 4.46 [1.11–17.90] 0.0351 | 2.92 [0.95–8.99] 0.0623 | 1.58 [0.86–2.90] 0.1399 | |||
TT CT + CC Recessive model | 7 19 | 0 18 | 4 26 | 2 28 | 8 83 | 6 89 |
OR[CI 95%] P value | 14.23 [0.76–267.20] 0.0759 | 2.15 [0.36–12.76] 0.3980 | 1.42 [0.48–4.29] 0.5241 | |||
TT CC Homozygote model | 7 7 | 0 13 | 4 12 | 2 20 | 8 42 | 6 55 |
OR[CI 95%] P value | 27.00 [1.35–541.60] 0.0312 | 3.33 [0.53–21.03] 0.2002 | 1.75 [0.56–5.42] 0.3346 | |||
T C | 26 26 | 5 31 | 18 38 | 12 48 | 57 125 | 46 144 |
OR [CI 95%] P value | 6.2 [2.08–18.44] 0.001 | 2.32 [1.02–5.27] 0.05 | 1.43 [0.90–2.25] 0.126 | |||
Phet | 0.001 | 0.002 | 0.001 | |||