Association between MTHFR C677T variant and risk for congenital heart defects in Egyptian children: a case–control study including meta-analysis based on 147 cases and 143 controls

Egyptian Journal of Medical Human Genetics

Table 5 Stratified analyses of the MTHFR C667T polymorphism in association with CHDs risk under the allelic model

Models of inheritance	2012–2021		Association test	Heterogeneity test			Effect model
Models of inheritance	Cases N = 147	Control N = 143	OR[CI 95%] P value	Q	P_het	I²* (%)	Effect model
CT + TT CC Dominant model	86 61	55 88	2.26 [1.41–3.61] 0.0003	27.00	< 0.01	96.3	Random
CT CC Heterozygote model	67 61	47 88	2.01 [1.25–3.38] 0.0021	26.00	< 0.01	96.2	Random
TT CT + CC Recessive model	19 128	8 135	2.50 [1.06–5.92] 0.018	11.00	< 0.01	91	Random
TT CC Homozygote model	19 61	8 88	3.42 [1.41–8.33] 0.0033	11.00	< 0.01	91	Random
T C	101 189	63 223	1.89 [1.31–2.74] 0.0004	38.00	< 0.01	97.4	Random