Table 5 Genotype and allelic frequency, the OR [95%CI], and P value of risk allele compared to wild allele at three categories of Gleason score, PSA and Perineural invasion
rs16260 | AA n (%) | AC n (%) | CC n (%) | A | C | OR (95%CI) | P Value | ||
|---|---|---|---|---|---|---|---|---|---|
Control | 0 (0.0) | 37 (37.8) | 61 (62.2) | 37 (18.9) | 159 (81.1) | 1 (reference) | _ | ||
Gleason score | ≥ 8 | 0 (0.0) | 16 (48.5) | 17 (51.5) | 16 (24.2) | 50 (75.8) | 1.375 (0.706–2.679) | 0.377 | |
= 7 | 1 (2.1) | 27 (56.3) | 20 (41.7) | 28 (29.5) | 67 (70.5) | 1.796(1.018–3.169) | 0.042 | ||
7 > | 1 (4.8) | 10 (47.6) | 10 (47.6) | 11 (26.8) | 30 (73.2) | 1.576 (0.724–3.430) | 0.249 | ||
PSA | ≤ 4 | Case | 0 (0.0%) | 7 (70.0) | 3 (30.0) | 7 (35.0) | 13 (65.0) | 2.513 (0.703–8.979 | 0.194 |
Control | 0 (0.0%) | 6 (35.3) | 11 (64.7) | 6 (17.6) | 28 (82.4) | ||||
4.1–10 | Case | 0 (0.0%) | 20 (46.5) | 23 (53.5) | 20 (23.3) | 66 (76.7) | 1.212 (0.611–2.403) | 0.581 | |
Control | 0 (0.0%) | 22 (40.0) | 33 (60.0) | 22 (20.0) | 88 (80.0) | ||||
> 10 | Case | 2 (4.1%) | 26 (53.1) | 21 (42.9) | 30 (30.6) | 68 (69.4) | 2.108 (0.913–4.868) | 0.077 | |
Control | 0 (0.0%) | 9 (34.6) | 17 (65.4) | 9 (17.3) | 43 (82.7) | ||||
Perineural invasion | + | 0 (0.0) | 37 (52.1) | 34 (47.9) | 0.093 | ||||
− | 2 (6.5) | 16 (51.6) | 13 (41.9) |