The role of miRNAs in the diagnosis and treatment of male infertility: a review study

Egyptian Journal of Medical Human Genetics

Table 1 miRNAs in SSC self-renewal and differentiation

miRNAs	Location	Action	Result	Refs.
miR-20 miR-106a	SSCs	Expressed in mouse SSCs, targeting STAT3 and Ccnd1	Help maintain and SSC homeostasis in mouse	[20]
miR-21	SSCs	Decreased apoptosis by increasing the expression of miR-21	Maintaining the SSC population	[21]
miRNA-554	SSCs	Targeting PLZF	Self-renewal of SSCs in goats	[22]
miR-135a	SSCs	Modulating FoxO1 activity	Help maintain SSCs	[23]
miR-34c	SSCs	Expression in goats	Increasing apoptosis of SSCs and reducing their proliferation dependent on P53	[24]
miR-let 7-family	SSCs	Down regulating	Differentiation of spermatogonia and entry into meiosis	[26]
miR-17-29 miR-106b-25	SSCs	Down regulating Up regulating	Shrinking of the testis and occurrence of oligospermia in mice	[27]
miR-221 miR-222	SSCs	Exposed to RA: down-regulating Exposed to GDNF: up regulating	Occurrence of disorder caused by the loss of differentiation ability	[17]
miR-146	SSCs	Regulation and control of retinoic acid	High expression level in differentiated cell	[28]