A computational analysis reveals eight novel high-risk single nucleotide variants of human tumor suppressor LHPP gene

Egyptian Journal of Medical Human Genetics

Table 4 Swiss PDB Viewer result

RSID	A.A change	Presence of clash/hydrogen bond	Number of rotamer	Energy minimization (kj/mol)
rs142386969	G227R	Both	28	− 20,735.715
rs143345981	R234C	H bond	3	− 20,101.102
rs199534407	I212T	H bond	3	− 20,422.918
rs531050111	Y172S	Both	3	− 20,290.529
rs573011028	L231P	Both	2	− 20,397.299
rs573011028	L231R	Both	28	− 20,667.475
rs754022892	L22P	Both	2	− 20,362.113
rs759890361	N55T	H bond	3	− 20,239.061
rs759928988	G236R	Both	28	− 20,321.631
rs759928988	G236W	Both	2	− 19,142.076
rs766371253	L91P	Both	2	− 20,071.346
rs778152634	R51S	Both	3	− 20,224.369
rs778834983	D219N	Both	5	− 20,225.535
rs899597192	V80G	H bond	1	− 20,304.168
rs984607794	Y23N	Both	5	− 20,482.748
rs984607794	Y23D	Both	6	− 20,293.883
rs1202486494	V233M	Both	13	− 20,469.342
rs1263254735	D214G	H bond	1	− 20,157.153
rs1309201353	V186E	Both	14	− 20,409.354
rs1311232035	G13R	Both	28	− 19,331.146
rs1311232035	G13W	Both	7	− 18,770.787
rs1361592111	R234P	Both	2	− 19,645.45
rs1382625953	G29C	Both	3	− 20,396.191
rs1486839697	L68F	Both	5	− 18,906.451
rs1564759586	G35D	Both	8	− 20,461.344
rs1564805010	Q224P	Both	2	− 19,960.779
rs1589821103	V233G	H bond	1	− 20,313.127
	Wild protein			− 20,422.141