Association of serum miR-375, miR-155 and miR-146b levels with distinguish of papillary thyroid cancer from benign thyroid masses among Iranian patients

Egyptian Journal of Medical Human Genetics

Table 1 Candidate miRNAs for investigation in the serum of PTC patients

miRNAs of interest	Target genes functional activity, previous association with PTC	References
miR-375	ERBB2, overexpression of this miRNA increases cell proliferation and reduces apoptosis	[15, 16]
miR-155	APC, it activates the β-catenin pathway, which in turn leads to activation of downstream pathways such as C-MYC and TCF	[17]
miR-146b	SMAD4, P27, when this miRNA is inhibited, migration and invasion are significantly reduced in cell lines, and migration and invasion are increased by increasing its expression	[18,19,20,21]