An exploratory pharmacogenetic screening of SLC22A6, SLC22A8, ABCC4 and ABCC10 genes in a cohort of Ghanaian HBV patients

Egyptian Journal of Medical Human Genetics

Table 3 Distribution of different genotypes in overall population and patients based on non-graded CKD categories

Genotype	Overall population, N = 160; n (%)	^σeGFR > 60 mL/min/1.73 m², N = 122; n (%)	^σeGFR < 60 mL/min/1.73 m² N = 38; n (%)	P*
SLC22A6 rs12293966 A > G
AA	76 (47.50)	52 (42.62)	24 (63.57)	0.209
GA	64 (40.00)	56 (45.90)	8 (21.05)
GG	20 (12.50)	14 (11.48)	6 (15.79)
HWE-p^Δ	0.264
SLC22A6 rs4149170 C > T
CC	63 (39.38)	46 (37.70)	17 (44.74)	0.446
TC	40 (25.00)	31 (25.41)	9 (23.68)
TT	57 (35.62)	45 (36.89)	12 (31.57)
HWE-p^Δ	0.001
SLC22A6 rs6591722 T > A
TT	140 (87.50)	107 (87.71)	33 (27.05)	0.889
AT	20 (12.50)	15 (12.29)	5 (13.15)
AA	00(0.00)	0 (0.00)	0 (0.00)
HWE-p^Δ	0.399
SLC22A6 rs955434 G > A
GG	132 (82.50)	102 (83.61)	30 (78.95)	0.512
GA	28 (17.50)	20 (16.39)	8 (21.05)
AA	0 (00)	0 (0.00)	0 (0.00)
HWE-p^Δ	0.225
ABCC10 rs700008 A > G
AA	28 (17.50)	23 (18.85)	5 (13.16)	0.423
GA	0 (00)	0 (0.00)	0
GG	132 (82.50)	99 (81.15)	33 (86.84)
HWE-p^Δ	0.001
ABCC10 rs831311 C > T
CC	105 (65.62)	83 (68.03)	22 (57.89)	0.245
TC	49 (30.62)	35 (28.69)	14 (36.84)
TT	6 (3.75)	4 (3.25)	2 (5.26)
HWE-p^Δ	0.145
ABCC4 rs9282570 T > C
TT	145 (90.62)	110 (90.16)	35 (92.10)	0.581
TC	13 (8.12)	10 (8.20)	3 (7.90)
CC	2 (1.25)
HWE-p^Δ	0.015
SLC22A8 rs11568487 G > T
GG	149 (93.12)	113 (92.62)	36 (94.74)	0.655
GT	11 (6.88)	9 (7.37)	2 (5.26)
TT	0 (00)	0 (0.00)	0 (0.00)
HWE-p^Δ	0.652

*HWE-p^Δ—Hardy Weinberg p values, p^Δ represents the chi square test to compare genotype frequencies. If the p < 0.05 depicts inconsistency with HWE
^σThe two categories were based on the NKF/KDOQI guidelines[33]