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Egyptian Journal of Medical Human Genetics

Table 6 Association between eGFR and SNPs under multiple models of inheritance

From: An exploratory pharmacogenetic screening of SLC22A6, SLC22A8, ABCC4 and ABCC10 genes in a cohort of Ghanaian HBV patients

Inheritance MODEL

Alleles

CRUDE MODEL

MODEL 1

MODEL2

SNP

OR (95%)

p value

OR (95%)

p value

OR (95%)

p value

SLC22A6 rs955434

Dominant

GA-AA

1.54 (0.35–6.82)

0.570

1.50 (0.33–6.74)

0.53

1.13 (0.33–3.80)

0.211

Recessive

AA

–

 

–

 

–

 

Codominant

GA

2.05 (0.57–7.39)

0.271

1.78 (0.51–6.19)

0.366

1.14 (0.41–3.20)

0.800

SLC22A6 rs12293966

Dominant

GA-GG

0.27 (0.08–0.81)

0.019

0.33 (0.08–1.23)

0.099

0.35(0.11–1.09)

0.070

Recessive

GG

1.45 (0.51–4.07)

0.48

0.64 (0.09–4.16)

0.641

1.69 (0.49–5.85)

0.41

Codominant

GA

0.21 (0.07–0.66)

0.008

1.76 (0.39–7.89)

0.014

0.30 (0.12–0.78)

0.013

SLC22A6 rs4149170

Dominant

TC-TT

3.90 (0.94–16.16)

0.061

1.58 (0.41–6.06)

0.507

1.46 (0.46–4.64)

0.52

Recessive

TT

0.91(0.38–2.13)

0.830

1.49(0.40–5.61)

0.55

0.82 (0.29–2.32)

0.71

Codominant

TC

0.87 (0.29–2.5)

0.806

0.91 (0.31–2.67)

0.863

1.19 (0.48–2.96)

0.700

SLC22A6 rs6591722

Dominant

AT-AA

0.52 (0.12–2.22)

0.380

0.81 (0.23–2.86)

0.747

0.95 (0.29–3.07)

0.93

Recessive

TT

–

 

–

 

–

 

Codominant

AT

0.69 (0.18–2.59)

0.580

0.76 (0.21–2.73)

0.674

1.15 (0.37–3.67)

0.802

SLC22A8 rs11568487

Dominant

GT-TT

0.92 (0.10–8.11)

0.701

1.40 (0.20–9.82)

0.734

1.08 (0.20–5.77)

0.92

Recessive

TT

–

 

–

 

–

 

Codominant

GT

1.01 (0.13–7.36)

0.989

0.96 (0.13–6.87)

0.967

0.93 (0.18–4.87)

0.936

ABCC10 rs831311

Dominant

TC-TT

4.53 (0.38–54.25)

0.234

1.06 (0.41–2.69)

0.22

1.96 (0.30–12.93)

0.48

Recessive

TT

1.64(0.28–9.32)

0.58

2.05(0.26–16.26)

0.5

1.76 (0.30–10.27)

0.53

Codominant

TC

0.83 (0.30–2.31)

0.723

0.88 (0.32–2.37)

0.801

1.30 (0.57–2.94)

0.535

ABCC10 rs700008

Dominant

GA-GG

2.17 (0.51–9.18)

0.941

2.12 (0.52–8.57)

0.293

1.58 (0.53–4.72)

0.41

Recessive

GG

1.53 (0.54–4.36)

0.42

2.10(0.60–7.51)

0.25

1.45 (0.79–0.50)

0.5

Codominant

GA

–

 

–

 

–

 

ABCC4 rs9282570

Dominant

TC-CC

0.25 (0.04–1.49)

0.125

0.37 (0.06–2.05)

0.256

0.64 (0.15–2.66)

0.52

Recessive

CC

–

 

–

 

–

 

Codominant

TC

0.27 (0.04–1.70)

0.164

0.33 (0.06–1.94)

0.224

0.93 (0.18–4.87)

0.936

  1. CI Confidence interval, bolded values are statistically significant
  2. Model 1 Adjusted for duration of diagnosis, herbal medicine usage and medication usage
  3. Model 2 Adjusted model 1 + age, gender and BMI
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