Association of angiotensin-converting enzyme I/D polymorphism and apolipoprotein B with cardiometabolic abnormalities among young adults: a pilot study from Delhi

Egyptian Journal of Medical Human Genetics

Table 1 Distribution of genotypes and alleles of ACE I/D polymorphism with respect to cardiometabolic variables

Variables	ACE genotypes			p value	Allele frequency
Variables	II n (%)	ID n (%)	DD n (%)	p value	I	D
BP
Normotensive	29 (78.4)	59 (74.7)	47 (75.8)	0.91	0.43	0.57
Hypertensive	8 (21.6)	20 (25.3)	15 (24.2)		0.38	0.61
BMI
Non-obese	27 (73.0)	61 (77.2)	47 (75.8)	0.88	0.40	0.60
Overweight/Obese	10 (27.0)	18 (22.8)	15 (24.2)		0.39	0.60
WC
High	10 (27.0)	13 (16.5)	20 (32.3)	0.08	0.37	0.63
Normal	27 (73.0)	66 (83.5)	42 (67.7)		0.43	0.56
WHR
High	14 (37.8)	29 (36.7)	28 (45.2)	0.57	0.38	0.61
Normal	23 (62.2)	50 (63.3)	34 (54.8)		0.43	0.56
WHtR
High	12 (32.4)	20 (25.3)	26 (41.9)	0.11	0.36	0.63
Normal	25 (67.6)	59 (74.7)	36 (58.1)		0.43	0.56
TC
Abnormal	7 (18.1)	5 (6.3)	2 (3.2)	0.01*	0.67	0.33
Normal	30 (81.1)	74 (93.7)	60 (96.8)		0.41	0.59
TG
Abnormal	11 (29.7)	15 (19.0)	16 (25.8)	0.39	0.43	0.57
Normal	26 (70.3)	64 (81.0)	46 (74.2)		0.44	0.56
HDL
Normal	9 (24.3)	12 (15.2)	10 (16.1)	0.45	0.48	0.52
Abnormal	28 (75.7)	67 (84.8)	52 (83.9)		0.42	0.58
LDL
Abnormal	6 (16.2)	3 (3.8)	2 (3.2)	0.01*	0.68	0.32
Normal	31 (83.8)	76 (96.2)	60 (96.8)		0.41	0.59
FBG
Abnormal	1 (2.7)	10 (12.7)	8 (12.9)	0.21	0.32	0.68
Normal	36 (97.3)	69 (87.3)	54 (87.1)		0.44	0.56

BP, blood pressure; BMI, body mass index; WC, waist circumference; WHR, waist-hip ratio; WHtR, waist height ratio; TC, total cholesterol; TG, triglyceride; HDL, high-density lipoprotein; LDL, low-density lipoprotein; FBG, fasting blood glucose. II, insertion homozygote; ID, heterozygote; DD, deletion homozygote
*Significance at p value ≤ 0.05