Table 3 The relations between the studied parameters and the signs of cancer progression
From: The role of miRNA-29b1, MMP-2, MMP-9 mRNAs, and proteins in early diagnosis of HCC
|  | MMP-2 Protein ng/mL M ± SD | MMP-2 gene expression M ± SD | MMP-9 Protein ng/Ml M ± SD | MMP-9 gene expression M ± SD | miRNA-29b1 expression M ± SD | AFP ng/mL Median |
|---|---|---|---|---|---|---|
Tumor nodules | ||||||
Single ≤ 5cm (n = 27) | 354 ± 70 | 2.025 ± .45 | 326 ± 80 | 1.31 ± .23 | 0.77 ± .05 | 203 |
Single ≥ 5cm (n = 2) | 478 ± 12 | 2.35 ± .35 | 426 ± 74 | 1.13 ± .042 | 0.83 ± .063 | 286 |
Multiple ≤ 5 cm (n = 22) | 374 ± 130 | 2.32 ± .41 | 339 ± 78 | 1.37 ± .27 | 0.78 ± .033 | v |
Multiple ≥ 5 cm (n = 1) | 278 ± 00 P ˃ 0.05 | 2.7 ± .00 P ˃ 0.05 | 326 ± 00 P ˃ 0.05 | 1.2 ± 00 P ˃ 0.05 | 0.74 ± 00 P ˃ 0.05 | 400 P ˃ 0.05 |
Tumor grade (I–II–III–IV) | ||||||
II (n = 28) | 365 ± 85 | 2.065 ± . | 314 ± 8 | 1.2 ± .24 | 0.76 ± .036 | 210 |
III (n = 24) | 368 ± 119 P ˃ 0.05 | 382.30 ± .50 P ˃ 0.05 | 3360 ± 67 P ˃ 0.05 | 1.4 ± .23P ˃ 0.05 | 0.76 ± .10 P ˃ 0.05 | 201 P ˃ 0.05 |
TNM staging (I–II–III–IV) | ||||||
IB (n = 4) | 433.7 ± 51 | 1.62 ± .323 | 372 ± 36 | 1.34 ± .36 | 0.74 ± .043 | 505 |
II (n = 24) | 353.1 ± 85 | 2.1 ± .34 | 305 ± 85 | 1.25 ± .22 | 0.78 ± .058 | 168 |
IIIA (n = 18) | 358 ± 131 | 2.37 ± .44 | 366 ± 73 | 1.35 ± .21 | 0.77 ± .055 | 188 |
IIIB (n = 6) | 397 ± 67 P ˃ 0.05 | 2.00 ± .65 P ˃ 0.05 | 343 ± 44 P ˃ 0.05 | 1.5 ± .25 P ˃ 0.05 | 0.80 ± .057 P ˃ 0.05 | 204 P ˃ 0.05 |
Metastasis | ||||||
One organ | 364 ± 83 | 2.1 ± .41 | 323 ± 81 | 1.28 ± .22 | 0.78 ± .059 | 210 |
˃ one organ | 370 ± .129 P ˃ 0.05 | 2.22 ± .52 P ˃ 0.05 | 358 ± 71 P ˃ 0.05 | 1.41 ± .26 P ˃ 0.05 | 0.78 ± .052 P ˃ 0.05 | 200 P ˃ 0.05 |