Investigating the importance of EGFR (− 216G/T), Exo1 (K589E) and LEP (− 2548G/A) gene polymorphisms with risk of lung cancer as potential diagnostic biomarker in Iranian population

Egyptian Journal of Medical Human Genetics

Table 4 The analysis association between genotypes of SNPs studied with TNM staging system

Gene	SNP	Genotype	Tumor grade		OR*	95% CI*	P*
Gene	SNP	Genotype	T1 + T2, n (%)	T3 + T4, n (%)	OR*	95% CI*	P*
EGFR	rs712829	GG	14 (14)	16 (16)	1.00 (Reference)	1.00
		GT	24 (24)	31 (31)	0.898	0.330–1.442	0.833
		TT	2 (2)	13 (13)	0.236	0.042–1.317	0.100
Exo1	rs1047840	AA	9 (9)	11 (11)	1.00 (Reference)	1.00
		GA	11 (11)	11 (11)	1.286	0.332–4.972	0.716
		GG	20 (20)	38 (38)	0.686	0.215–1.186	0.524
LEP	rs7799039	GG	10 (10)	6 (6)	1.00 (Reference)	1.00
		GA	14 (14)	39 (39)	0.222	0.060–0.824	0.024
		AA	16 (16)	15 (15)	0.677	0.153–1.652	0.576

Gene	SNP	Genotype	Lymph node status		OR*	95% CI*	P*
Gene	SNP	Genotype	N−, n (%)	N+, n (%)	OR*	95% CI*	P*
EGFR	rs712829	GG	12 (12)	18 (18)	1.00 (Reference)	1.00
		GT	23 (23)	32 (32)	0.969	0.353–1.661	0.952
		TT	5 (5)	10 (10)	0.700	0.164–1.481	0.629
Exo1	rs1047840	AA	10 (10)	10 (10)	1.00 (Reference)	1.00
		GA	7 (7)	15 (15)	0.500	0.125–1.009	0.327
		GG	23 (23)	35 (35)	0.643	0.205–1.020	0.449
LEP	rs7799039	GG	5 (5)	11 (11)	1.00 (Reference)	1.00
		GA	20 (20)	33 (33)	0.722	0.191–1.737	0.632
		AA	15 (15)	16 (16)	0.481	0.117–0.982	0.311

Gene	SNP	Genotype	Metastatic status		OR*	95% CI*	P*
Gene	SNP	Genotype	M−, n (%)	M+, n (%)	OR*	95% CI*	P*
EGFR	rs712829	GG	10 (10)	20 (20)	1.00 (Reference)	1.00
		GT	17 (18)	38 (38)	0.933	0.323–1.693	0.898
		TT	3 (3)	12 (12)	0.400	0.070–2.277	0.302
Exo1	rs1047840	AA	5 (5)	15 (15)	1.00 (Reference)	1.00
		GA	10 (10)	12 (12)	0.400	0.555–0.881	0.241
		GG	15 (15)	43 (43)	0.959	0.286–1.920	0.932
LEP	rs7799039	GG	6 (6)	10 (10)	1.00 (Reference)	1.00
		GA	15 (15)	38 (38)	0.490	0.174–0.954	0.502
		AA	9 (9)	22 (22)	0.422	0.151–0.869	0.512