Table 7 Interpretation of the impact of rs1047840 on Exo1 protein structure and stability by HOPE
Gene | SNP ID (Amino Acid Change) | Size | Charge | Hydrophobicity | Interpretation | |
|---|---|---|---|---|---|---|
EXO1 | rs1047840 (E589K) | W > M | Positive > Negative | Decrease | The mutated residue is located in a domain that is important for the main activity of the protein. This mutation might lead to loss of function and interactions | |